Interactor 1: RB (P13405)
Retinoblastoma-associated protein (p110-RB1) (pRb) (Rb) (pp105)
Gene: Rb1

Interactor 2: E2F1 (Q61501)
Transcription factor E2F1 (E2F-1)
Gene: E2F1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.829

The method score is based on:

Property Details
Experiments 28559429, 30109252, 12799438
Identification Methods affinity chromatography technology, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains E2F_CC-MB~Rb_C
Common GO terms GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 8 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 921
Mm

1 430
+ Rn
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ At
+ At
+ At
+ Hs
+ Ce
+ Dm
+ Dm
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024