Protein: ORC5
Origin recognition complex subunit 5 (Origin recognition complex 53 kDa subunit)

Gene: ORC5
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P50874

Gene Ontology (top 5):
GO:0003688 - DNA replication origin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005656 - nuclear pre-replicative complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

745656

ORC2
Origin recognition complex subunit 2

14

4

Small-scale

0.982

High

898171

ORC4
Origin recognition complex subunit 4

11

13

Small-scale

0.980

High

898169

ORC1
Origin recognition complex subunit 1

13

13

Small-scale

0.978

High

898170

ORC3
Origin recognition complex subunit 3

8

0

Small-scale

0.916

High

713007

MCM2
DNA replication licensing factor MCM2

4

6

Small-scale

0.901

High

898167

ORC5
Origin recognition complex subunit 5

3

2

Small-scale

0.849

High

479272

CDC6
Cell division control protein 6

6

14

Small-scale

0.726

High

805518

ORC6
Origin recognition complex subunit 6

7

0

Small-scale

0.715

High

793887

PCH2
Pachytene checkpoint protein 2

1

0

Small-scale

0.687

High

865454

CDT1
Cell division cycle protein CDT1

3

0

Small-scale

0.633

High

898178

HAT1
Histone acetyltransferase type B catalytic subunit

3

0

Small-scale

0.622

High

713282

MCM5
Minichromosome maintenance protein 5

1

7

Small-scale

0.618

High

721387

MCM4
DNA replication licensing factor MCM4

1

7

Small-scale

0.618

High

803754

RRM3
ATP-dependent DNA helicase RRM3

2

0

Small-scale

0.609

High

381567

H2B2
Histone H2B.2

2

2

High-throughput

0.601

High

898179

CAF1A
Chromatin assembly factor 1 subunit A

2

0

Small-scale

0.583

High

816141

HAT2
Histone acetyltransferase type B subunit 2

2

0

Small-scale

0.576

High

898168

MCM6
DNA replication licensing factor MCM6

1

7

Small-scale

0.575

High

381169

H2B1
Histone H2B.1

2

2

High-throughput

0.571

High

524539

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.571

High

898174

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

1

0

Small-scale

0.565

High

858410

SUM1
Suppressor of mar1-1 protein

2

0

Small-scale

0.559

High

819247

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

High-throughput

0.552

High

752500

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.546

High

734268

DBF4
DDK kinase regulatory subunit DBF4

1

0

Small-scale

0.529

High

864604

CUL8
Cullin-8

1

0

Small-scale

0.525

High

488973

SWI6
Regulatory protein SWI6

1

0

Small-scale

0.518

High

662091

MPIP
M-phase inducer phosphatase

1

0

Small-scale

0.518

High

403578

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

High-throughput

0.513

High

735393

MCM10
Minichromosome maintenance protein 10

1

1

Small-scale

0.501

High

740592

IME2
Meiosis induction protein kinase IME2/SME1

1

0

Small-scale

0.480

High

382220

H4
Histone H4

1

1

High-throughput

0.479

High

898172

H3
Histone H3

1

3

High-throughput

0.479

High

808236

SHU2
Suppressor of hydroxyurea sensitivity protein 2

1

0

Small-scale

0.460

High

824971

CSM2
Chromosome segregation in meiosis protein 2

1

0

Small-scale

0.460

High

898176

NOC3
Nucleolar complex-associated protein 3

1

0

Small-scale

0.460

High

898177

PSY3
Platinum sensitivity protein 3

1

0

Small-scale

0.460

High

419807

H2A2
Histone H2A.2

1

0

High-throughput

0.458

High

639564

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.458

High

707626

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

718950

CGS5
S-phase entry cyclin-5

1

0

Small-scale

0.458

High

824987

FKH1
Fork head protein homolog 1

1

0

Small-scale

0.458

High

527156

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

545539

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

741965

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

779557

LHS1
Heat shock protein 70 homolog LHS1

1

2

High-throughput

0.445

High

676160

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

781765

SET3
SET domain-containing protein 3

1

0

High-throughput

0.426

High

844416

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

795097

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

898175

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

795631

YBH1
Uncharacterized protein YBL071C

1

0

High-throughput

0.238

Low

823276

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.232

Low

898173

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025