HitPredict

Interactor 1: BMP1 (P13497)
Bone morphogenetic protein 1 (BMP-1) (EC 3.4.24.19) (Mammalian tolloid protein) (mTld) (Procollagen C-proteinase) (PCP)
Gene: BMP1

Interactor 2: PCOC1 (Q15113)
Procollagen C-endopeptidase enhancer 1 (Procollagen COOH-terminal proteinase enhancer 1) (PCPE-1) (Procollagen C-proteinase enhancer 1) (Type 1 procollagen C-proteinase enhancer protein) (Type I procollagen COOH-terminal proteinase enhancer)
Gene: PCOLCE

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	18164932, 20207734
Identification Methods	protease assay, surface plasmon resonance
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CUB~CUB, CUB~EGF_CA, CUB~FXa_inhibition
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0006508 - proteolysis
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 986 Hs			1 449
+	Hs
		216998 TLL1_HUMAN (27-986): 0: 955: 72.55		BMP1_HUMAN (3-154): 7.63e-31: 127: 26.28
+	Hs
		528146 TLL2_HUMAN (21-986): 0: 948: 74.16		BMP1_HUMAN (3-154): 7.63e-31: 127: 26.28
+	Hs
		528067 BMP1_HUMAN (1-986): 0: 943: 100.00		BMP1_HUMAN (3-154): 7.63e-31: 127: 26.28
+	Hs
		1378154 TLL2_HUMAN (21-986): 0: 948: 74.16		ST14_HUMAN (170-392): 6.31e-24: 107: 21.03
+	Hs
		1356682 ST14_HUMAN (446-882): 1.63e-24: 112: 17.96		PCOC2_HUMAN (31-437): 1.98e-126: 374: 44.61
+	Ss
		94581 CUBN_PIG (745-975): 3.64e-37: 154: 26.72		CUBN_PIG (2-394): 6.13e-48: 179: 20.15
+	Rn
		250561 CUBN_RAT (538-981): 8.5e-49: 191: 15.76		CUBN_RAT (1-147): 1.21e-30: 127: 29.33
+	Hs
		1241181 NETO2_HUMAN (315-602): 3.88e-56: 205: 24.37		ST14_HUMAN (170-392): 6.31e-24: 107: 21.03
+	Hs
		155193 NRP1_HUMAN (870-983): 9.78e-25: 113: 31.03		NRP1_HUMAN (1-172): 4.46e-40: 155: 26.37
+	Hs
		155217 NRP2_HUMAN (858-984): 8.38e-25: 113: 27.61		NRP1_HUMAN (1-172): 4.46e-40: 155: 26.37
+	Hs
		234413 NRP2_HUMAN (858-984): 8.38e-25: 113: 27.61		NRP2_HUMAN (143-400): 7.5e-38: 148: 24.52
+	Hs
		822570 MASP1_HUMAN (136-520): 1.46e-25: 115: 14.50		MASP1_HUMAN (142-422): 3.81e-27: 116: 17.49
+	Hs
		234451 NRP2_HUMAN (858-984): 8.38e-25: 113: 27.61		ST14_HUMAN (170-392): 6.31e-24: 107: 21.03
+	Hs
		119686 MASP1_HUMAN (136-520): 1.46e-25: 115: 14.50		MASP2_HUMAN (168-348): 5.24e-16: 82.5: 23.04