HitPredict

Interactor 1: CCL2 (P13500)
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Gene: CCL2

Interactor 2: STAT1 (P42224)
Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
Gene: STAT1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	17167270, 11022002, 17255531
Identification Methods	electrophoretic mobility supershift assay, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007259 - cell surface receptor signaling pathway via JAK-STAT GO:0051770 - positive regulation of nitric-oxide synthase biosynthetic process GO:0071346 - cellular response to type II interferon
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 99 Hs			1 750
+	Hs
		786415 CCL19_HUMAN (27-98): 3.23e-20: 79.2: 24.66		STAT1_HUMAN (1-750): 0: 988: 100.00
+	Hs
		528212 CCL2_HUMAN (1-99): 2.3e-33: 112: 100.00		STAT2_HUMAN (1-725): 0: 770: 43.03
+	Hs
		855319 CCL19_HUMAN (27-98): 3.23e-20: 79.2: 24.66		STAT2_HUMAN (1-725): 0: 770: 43.03
+	Hs
		786470 CCL11_HUMAN (1-98): 1.83e-30: 105: 70.41		STAT6_HUMAN (1-740): 0: 638: 26.43
+	Hs
		786506 CCL26_HUMAN (23-91): 4.53e-21: 81.6: 30.44		STAT6_HUMAN (1-740): 0: 638: 26.43