Protein: THIOM
Thioredoxin, mitochondrial (MTRX) (Mt-Trx) (Thioredoxin-2)

Gene: THIOM, TXN2
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q99757

Gene Ontology (top 5):
GO:0005730 - nucleolus
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0015035 - protein-disulfide reductase activity
GO:0045454 - cell redox homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1307513

RBM45
RNA-binding protein 45

3

1

High-throughput

0.779

High

1407195

TXNIP
Thioredoxin-interacting protein

3

6

Small-scale

0.770

High

49499

CIB4
Calcium and integrin-binding family member 4

2

2

High-throughput

0.700

High

666764

MYL9
Myosin regulatory light polypeptide 9

2

4

High-throughput

0.700

High

880466

RPIA
Ribose-5-phosphate isomerase

3

1

High-throughput

0.675

High

1316283

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

4

1

High-throughput

0.637

High

623502

RO52
E3 ubiquitin-protein ligase TRIM21

3

7

High-throughput

0.616

High

989091

AP2B1
AP-2 complex subunit beta

3

1

High-throughput

0.616

High

1150072

MARE2
Microtubule-associated protein RP/EB family member 2

3

6

High-throughput

0.616

High

1205958

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

5

High-throughput

0.616

High

1385799

COAC
Phosphopantothenoylcysteine decarboxylase

3

1

High-throughput

0.616

High

1393536

MR1L1
MORF4 family-associated protein 1-like 1

3

2

High-throughput

0.616

High

1407211

MARE3
Microtubule-associated protein RP/EB family member 3

3

6

High-throughput

0.616

High

339377

ETHE1
Persulfide dioxygenase ETHE1, mitochondrial

2

1

High-throughput

0.606

High

1407204

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.606

High

959923

RS3A
Small ribosomal subunit protein eS1

2

2

High-throughput

0.601

High

1386946

GASP2
G-protein coupled receptor-associated sorting protein 2

3

2

High-throughput

0.597

High

452382

PDIA1
Protein disulfide-isomerase

1

19

High-throughput

0.590

High

1045695

TF65
Transcription factor p65

3

4

Small-scale

0.581

High

298063

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.580

High

775463

DDIT3
DNA damage-inducible transcript 3 protein

2

0

High-throughput

0.580

High

1407189

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

2

0

High-throughput

0.580

High

229360

ZBT14
Zinc finger and BTB domain-containing protein 14

1

2

High-throughput

0.573

High

1407209

RABX5
Rab5 GDP/GTP exchange factor

1

4

High-throughput

0.573

High

1407210

CHIP
E3 ubiquitin-protein ligase CHIP

1

7

High-throughput

0.573

High

404372

GCR
Glucocorticoid receptor

1

12

Small-scale

0.561

High

1400328

FMNL2
Formin-like protein 2

2

1

High-throughput

0.560

High

65145

GG6L9
Golgin subfamily A member 6-like protein 9

2

6

High-throughput

0.553

High

191772

MAGB2
Melanoma-associated antigen B2

2

2

High-throughput

0.553

High

386482

SPTA1
Spectrin alpha chain, erythrocytic 1

2

5

High-throughput

0.553

High

848344

MAGA4
Melanoma-associated antigen 4

2

2

High-throughput

0.553

High

1009705

NGAL
Neutrophil gelatinase-associated lipocalin

2

2

High-throughput

0.553

High

1216152

FHL5
Four and a half LIM domains protein 5

2

2

High-throughput

0.553

High

1226847

KAZRN
Kazrin

2

1

High-throughput

0.553

High

1244640

GASP3
G protein-coupled receptor associated sorting protein 3

2

2

High-throughput

0.553

High

1277614

K1C27
Keratin, type I cytoskeletal 27

2

2

High-throughput

0.553

High

1324483

AN36B
Ankyrin repeat domain-containing protein 36B

2

6

High-throughput

0.553

High

1327012

EFC4A
EF-hand calcium-binding domain-containing protein 4A

2

2

High-throughput

0.553

High

1403308

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

6

High-throughput

0.553

High

1407191

GTPB2
GTP-binding protein 2

2

3

High-throughput

0.553

High

1407198

CHM1A
Charged multivesicular body protein 1a

2

4

High-throughput

0.553

High

1407203

ABI3
ABI gene family member 3

2

3

High-throughput

0.553

High

1407213

MOFA1
MORF4 family-associated protein 1

2

2

High-throughput

0.553

High

1406376

M3K5
Mitogen-activated protein kinase kinase kinase 5

2

7

Small-scale

0.533

High

848929

MAGAB
Melanoma-associated antigen 11

1

2

High-throughput

0.523

High

960535

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.523

High

1151632

TRIP6
Thyroid receptor-interacting protein 6

1

3

High-throughput

0.523

High

1230223

K1C40
Keratin, type I cytoskeletal 40

1

6

High-throughput

0.523

High

1397801

ODAD1
Outer dynein arm-docking complex subunit 1

1

7

High-throughput

0.523

High

1407212

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

11

Small-scale

0.501

High

1407208

PRAF1
Prenylated Rab acceptor protein 1

1

1

High-throughput

0.494

High

227954

MYO1B
Unconventional myosin-Ib

1

4

High-throughput

0.489

High

867375

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.489

High

1407199

ANLN
Anillin

1

2

High-throughput

0.489

High

436984

K1C18
Keratin, type I cytoskeletal 18

1

2

High-throughput

0.481

High

1232539

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

1252740

Q6ZN96
cDNA FLJ16308 fis, clone PUAEN2006335

1

1

High-throughput

0.470

High

827472

MLH1
DNA mismatch repair protein Mlh1

1

1

Small-scale

0.464

High

421199

ALDOB
Fructose-bisphosphate aldolase B

1

9

High-throughput

0.439

High

474924

VIME
Vimentin

1

5

High-throughput

0.439

High

894116

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.439

High

1407201

ZSC32
Zinc finger and SCAN domain-containing protein 32

1

5

High-throughput

0.439

High

106540

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

325999

UBR5
E3 ubiquitin-protein ligase UBR5

1

10

Small-scale

0.437

High

521888

H14
Histone H1.4

1

3

High-throughput

0.437

High

596317

H12
Histone H1.2

1

3

High-throughput

0.437

High

1407207

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.437

High

528502

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.426

High

366372

PLMN
Plasminogen

1

2

High-throughput

0.417

High

387879

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

5

High-throughput

0.417

High

388004

FIBG
Fibrinogen gamma chain

1

5

High-throughput

0.417

High

399617

VTNC
Vitronectin

1

1

High-throughput

0.417

High

715737

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.417

High

993306

ACTG
Actin, cytoplasmic 2

1

7

High-throughput

0.417

High

1198364

Q53ET4
Serine hydroxymethyltransferase

1

3

High-throughput

0.417

High

1277772

MYH14
Myosin-14

1

1

High-throughput

0.417

High

404884

PRIO
Major prion protein

1

1

High-throughput

0.407

High

228044

SSNA1
Microtubule nucleation factor SSNA1

3

0

High-throughput

0.352

High

1247402

ATRAP
Type-1 angiotensin II receptor-associated protein

3

0

High-throughput

0.352

High

1323333

VPS52
Vacuolar protein sorting-associated protein 52 homolog

3

0

High-throughput

0.352

High

1393436

REEP6
Receptor expression-enhancing protein 6

3

0

High-throughput

0.352

High

377070

COLI
Pro-opiomelanocortin

2

0

High-throughput

0.316

High

639636

SAT1
Diamine acetyltransferase 1

2

0

High-throughput

0.316

High

828437

PEX19
Peroxisomal biogenesis factor 19

2

0

High-throughput

0.316

High

1205357

TTC32
Tetratricopeptide repeat protein 32

2

0

High-throughput

0.316

High

1322133

SYCE1
Synaptonemal complex central element protein 1

2

0

High-throughput

0.316

High

1340329

CEP70
Centrosomal protein of 70 kDa

2

0

High-throughput

0.316

High

1350349

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.316

High

1386274

HAUS1
HAUS augmin-like complex subunit 1

2

0

High-throughput

0.316

High

1399216

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

1407060

MDFI
MyoD family inhibitor

2

0

High-throughput

0.316

High

1407190

HAUS8
HAUS augmin-like complex subunit 8

2

0

High-throughput

0.316

High

1407192

CDCA4
Cell division cycle-associated protein 4

2

0

High-throughput

0.316

High

1407193

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1407196

STN1
CST complex subunit STN1

2

0

High-throughput

0.316

High

1407197

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

2

0

High-throughput

0.316

High

1407202

TMOD4
Tropomodulin-4

2

0

High-throughput

0.316

High

1407206

CGBP1
CGG triplet repeat-binding protein 1

2

0

High-throughput

0.316

High

733881

DCTD
Deoxycytidylate deaminase

1

0

High-throughput

0.299

High

1316971

FAM9B
Protein FAM9B

1

0

High-throughput

0.299

High

1385948

TIFA
TRAF-interacting protein with FHA domain-containing protein A

1

0

High-throughput

0.299

High

1328464

CMIP6
Ciliary microtubule inner protein 6

1

0

High-throughput

0.279

Low

1397310

CMIP5
Ciliary microtubule inner protein 5

1

0

High-throughput

0.279

Low

352036

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

1

0

High-throughput

0.269

Low

1407205

I36RA
Interleukin-36 receptor antagonist protein

1

0

High-throughput

0.269

Low

843910

HD
Huntingtin

1

0

High-throughput

0.268

Low

1336088

CC197
Uncharacterized protein CCDC197

1

0

High-throughput

0.268

Low

1294625

NUTM1
NUT family member 1

1

0

High-throughput

0.251

Low

1407194

SHRPN
Sharpin

1

0

High-throughput

0.251

Low

1407200

THAP1
THAP domain-containing protein 1

1

0

High-throughput

0.251

Low

1126348

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025