HitPredict

Interactor 1: CCL2 (P13500)
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Gene: CCL2

Interactor 2: CCR3 (P51677)
C-C chemokine receptor type 3 (C C CKR3) (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR 3) (CKR3) (Eosinophil eotaxin receptor) (CD antigen CD193)
Gene: CCR3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	8642344
Identification Methods	pull down, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0007155 - cell adhesion GO:0006935 - chemotaxis GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 355
+	Mm
		500591 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR3_MOUSE (9-355): 3.86e-90: 276: 70.03
+	Hs
		561728 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		526560 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR1_HUMAN (1-355): 4.64e-89: 273: 62.54
+	Hs
		1305163 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR4_HUMAN (10-343): 1e-85: 264: 30.09
+	Mm
		486358 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		CCR2_MOUSE (4-355): 8.41e-83: 257: 51.41
+	Mm
		500590 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR1_MOUSE (1-355): 3.7e-83: 258: 58.03
+	Hs
		849619 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		783833 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR2_HUMAN (4-326): 8.26e-78: 245: 49.69
+	Hs
		561732 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		526564 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR3_HUMAN (1-355): 8.97e-80: 249: 100.00
+	Hs
		849654 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		561733 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Hs
		526565 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR5_HUMAN (5-355): 2.25e-74: 235: 49.58
+	Mm
		192790 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		CCRL2_MOUSE (44-318): 3.48e-55: 186: 38.79
+	Hs
		134400 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134356 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Hs
		134373 CCL8_HUMAN (1-98): 1.39e-33: 113: 69.39		ACKR2_HUMAN (10-325): 3.78e-53: 181: 37.74
+	Mm
		139696 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		ACKR2_MOUSE (16-343): 1.57e-46: 164: 34.55
+	Hs
		830629 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CXCR3_HUMAN (36-312): 4.4e-42: 152: 35.36
+	Hs
		526561 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CXCR5_HUMAN (5-318): 3.6e-41: 149: 30.34