Protein: CASP9
Caspase-9 (CASP-9) (EC 3.4.22.62) (Apoptotic protease Mch-6) (Apoptotic protease-activating factor 3) (APAF-3) (ICE-like apoptotic protease 6) (ICE-LAP6) [Cleaved into: Caspase-9 subunit p35; Caspase-9 subunit p10]

Gene: CASP9
Organism: Homo sapiens
Interactions: 69
UniProt ID: P55211

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001822 - kidney development
GO:0002931 - response to ischemia
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936938

XIAP
E3 ubiquitin-protein ligase XIAP

35

20

Small-scale

0.995

High

161704

APAF
Apoptotic protease-activating factor 1

21

5

Small-scale

0.988

High

936947

BIRC2
Baculoviral IAP repeat-containing protein 2

11

20

Small-scale

0.980

High

936964

BIRC7
Baculoviral IAP repeat-containing protein 7

7

20

Small-scale

0.969

High

840027

CASP3
Caspase-3

9

17

Small-scale

0.968

High

936971

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

5

20

Small-scale

0.934

High

936965

BIRC8
Baculoviral IAP repeat-containing protein 8

5

20

Small-scale

0.925

High

936946

BIRC3
Baculoviral IAP repeat-containing protein 3

5

20

Small-scale

0.922

High

936934

CASP9
Caspase-9

3

20

Small-scale

0.855

High

936898

CASP7
Caspase-7

2

19

Small-scale

0.799

High

936950

CASP8
Caspase-8

2

20

Small-scale

0.778

High

188659

BIRC5
Baculoviral IAP repeat-containing protein 5

2

20

Small-scale

0.754

High

936968

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

20

Small-scale

0.754

High

936945

ILK
Scaffold protein ILK

1

2

Small-scale

0.665

High

936972

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

20

Small-scale

0.665

High

936954

Q6PIA0
Baculoviral IAP repeat-containing 8

1

20

High-throughput

0.665

High

936943

BIRC1
Baculoviral IAP repeat-containing protein 1

1

20

Small-scale

0.647

High

936955

CASPC
Inactive caspase-12

1

20

Small-scale

0.647

High

936961

CASPA
Caspase-10

1

20

Small-scale

0.647

High

845960

DCC
Netrin receptor DCC

3

1

Small-scale

0.640

High

936941

B2CL1
Bcl-2-like protein 1

1

8

Small-scale

0.618

High

936962

RNF34
E3 ubiquitin-protein ligase RNF34

1

20

Small-scale

0.618

High

936970

B2L10
Bcl-2-like protein 10

1

1

Small-scale

0.618

High

936973

CARD8
Caspase recruitment domain-containing protein 8

1

10

Small-scale

0.618

High

362224

ABL1
Tyrosine-protein kinase ABL1

1

1

Small-scale

0.578

High

415463

HSPB1
Heat shock protein beta-1

2

10

High-throughput

0.571

High

452215

PDIA1
Protein disulfide-isomerase

2

3

High-throughput

0.571

High

481176

HMGB1
High mobility group protein B1

2

3

High-throughput

0.571

High

660011

COF1
Cofilin-1

2

1

High-throughput

0.571

High

936935

IF4A1
Eukaryotic initiation factor 4A-I

2

1

High-throughput

0.571

High

936936

ARP3
Actin-related protein 3

2

6

High-throughput

0.571

High

936939

AKA12
A-kinase anchor protein 12

2

1

High-throughput

0.571

High

936956

TRI72
Tripartite motif-containing protein 72

2

6

High-throughput

0.571

High

936949

PTC1
Protein patched homolog 1

2

0

Small-scale

0.559

High

936937

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.554

High

703516

MK01
Mitogen-activated protein kinase 1

1

5

Small-scale

0.550

High

361869

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

2

0

High-throughput

0.547

High

693278

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

Small-scale

0.536

High

936967

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.518

High

936951

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.517

High

936953

HECD3
E3 ubiquitin-protein ligase HECTD3

1

5

Small-scale

0.512

High

429595

JUN
Transcription factor Jun

1

4

Small-scale

0.501

High

442648

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.501

High

936966

RING2
E3 ubiquitin-protein ligase RING2

1

6

Small-scale

0.501

High

936940

KPCZ
Protein kinase C zeta type

1

5

Small-scale

0.484

High

130932

HIP1
Huntingtin-interacting protein 1

1

3

Small-scale

0.479

High

334162

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

1

Small-scale

0.479

High

384646

CRYAB
Alpha-crystallin B chain

1

10

Small-scale

0.479

High

474581

VIME
Vimentin

1

5

Small-scale

0.479

High

609637

LEG3
Galectin-3

1

2

Small-scale

0.479

High

691689

MK03
Mitogen-activated protein kinase 3

1

5

Small-scale

0.479

High

798903

BRCA1
Breast cancer type 1 susceptibility protein

1

5

Small-scale

0.479

High

934330

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

936942

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

936944

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

936948

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

936959

BICD2
Protein bicaudal D homolog 2

1

1

High-throughput

0.479

High

936974

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

2

Small-scale

0.479

High

906384

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.460

High

936957

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

936958

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

73877

HGB1A
High mobility group protein B1-like 1

1

3

High-throughput

0.445

High

400546

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

Small-scale

0.445

High

518739

GRAB
Granzyme B

1

12

Small-scale

0.445

High

936952

H90B2
Putative heat shock protein HSP 90-beta 2

1

3

High-throughput

0.445

High

936960

HDAC7
Histone deacetylase 7

1

6

Small-scale

0.445

High

936963

EFHD2
EF-hand domain-containing protein D2

1

1

Small-scale

0.437

High

936969

AMPB
Aminopeptidase B

2

0

High-throughput

0.298

High


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Last updated: 11Aug2025