HitPredict

Interactor 1: CCL2 (P13500)
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Gene: CCL2

Interactor 2: ACKR1 (Q16570)
Atypical chemokine receptor 1 (Duffy antigen/chemokine receptor) (Fy glycoprotein) (GpFy) (Glycoprotein D) (Plasmodium vivax receptor) (CD antigen CD234)
Gene: ACKR1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	13679391, 8132497
Identification Methods	pull down, competition binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006954 - inflammatory response GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 336
+	Mm
		486362 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		ACKR1_MOUSE (1-336): 5.06e-93: 282: 59.82
+	Hs
		849619 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR3_HUMAN (38-320): 6.5e-71: 225: 16.18
+	Hs
		849654 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR5_HUMAN (32-319): 8.1e-70: 223: 17.09
+	Hs
		526561 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CXCR5_HUMAN (55-319): 3.59e-71: 227: 17.75
+	Hs
		561732 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR3_HUMAN (38-320): 6.5e-71: 225: 16.18
+	Hs
		783833 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR2_HUMAN (16-322): 3.69e-68: 219: 17.07
+	Hs
		526564 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR3_HUMAN (38-320): 6.5e-71: 225: 16.18
+	Hs
		561733 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR5_HUMAN (32-319): 8.1e-70: 223: 17.09
+	Hs
		526565 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR5_HUMAN (32-319): 8.1e-70: 223: 17.09
+	Mm
		486358 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		CCR2_MOUSE (5-330): 8.74e-67: 215: 14.66
+	Hs
		1305163 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR4_HUMAN (20-332): 4.02e-65: 210: 11.75
+	Hs
		561728 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR1_HUMAN (43-322): 4.76e-67: 216: 14.43
+	Mm
		500591 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR3_MOUSE (25-321): 1.7e-67: 217: 16.00
+	Hs
		526560 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR1_HUMAN (43-322): 4.76e-67: 216: 14.43
+	Mm
		500590 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR1_MOUSE (43-322): 2.23e-60: 198: 13.77
+	Hs
		830629 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CXCR3_HUMAN (27-315): 3.94e-25: 105: 19.49
+	Hs
		134400 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR2_HUMAN (63-325): 2.7e-21: 95.1: 19.79
+	Hs
		134356 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		ACKR2_HUMAN (63-325): 2.7e-21: 95.1: 19.79
+	Hs
		134373 CCL8_HUMAN (1-98): 1.39e-33: 113: 69.39		ACKR2_HUMAN (63-325): 2.7e-21: 95.1: 19.79
+	Mm
		139696 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		ACKR2_MOUSE (99-325): 1.05e-18: 87.8: 19.84