Protein: UBP20
Ubiquitin carboxyl-terminal hydrolase 20 (EC 3.4.19.12) (Deubiquitinating enzyme 20) (Ubiquitin thioesterase 20) (Ubiquitin-specific-processing protease 20) (VHL-interacting deubiquitinating enzyme 2) (hVDU2)

Gene: UBP20, USP20
Organism: Homo sapiens
Interactions: 211
UniProt ID: Q9Y2K6

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460946

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

2

17

High-throughput

0.799

High

508863

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.755

High

333262

VAPB
Vesicle-associated membrane protein-associated protein B/C

7

6

High-throughput

0.748

High

1407284

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

6

4

High-throughput

0.734

High

343114

HERC2
E3 ubiquitin-protein ligase HERC2

6

15

Small-scale

0.732

High

1453852

VAPA
Vesicle-associated membrane protein-associated protein A

5

6

High-throughput

0.721

High

351411

CBX7
Chromobox protein homolog 7

5

7

High-throughput

0.716

High

946034

VSX2
Visual system homeobox 2

3

4

High-throughput

0.667

High

1460650

DBNL
Drebrin-like protein

3

11

High-throughput

0.667

High

1402025

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

20

High-throughput

0.647

High

1490806

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

20

High-throughput

0.647

High

1379894

FATE1
Fetal and adult testis-expressed transcript protein

3

0

High-throughput

0.646

High

1407142

MDFI
MyoD family inhibitor

3

0

High-throughput

0.646

High

1403234

MA7D2
MAP7 domain-containing protein 2

2

9

High-throughput

0.628

High

783458

TRI23
E3 ubiquitin-protein ligase TRIM23

2

5

High-throughput

0.628

High

1292892

STING
Stimulator of interferon genes protein

2

7

Small-scale

0.624

High

1490807

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.624

High

987504

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

6

Small-scale

0.618

High

996399

EF1A1
Elongation factor 1-alpha 1

1

6

Small-scale

0.618

High

1353438

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

17

Small-scale

0.618

High

1380269

FBXW7
F-box/WD repeat-containing protein 7

1

6

Small-scale

0.618

High

1490804

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

17

Small-scale

0.618

High

1314624

IHO1
Interactor of HORMAD1 protein 1

3

1

High-throughput

0.616

High

123881

MYO1C
Unconventional myosin-Ic

2

18

Small-scale

0.611

High

1458303

MYO1A
Unconventional myosin-Ia

2

20

Small-scale

0.611

High

936684

BRPF1
Peregrin

2

4

High-throughput

0.606

High

1006323

CTG1B
Cancer/testis antigen 1

2

1

High-throughput

0.606

High

1022690

ZXDB
Zinc finger X-linked protein ZXDB

2

2

High-throughput

0.606

High

1094159

RM28
Large ribosomal subunit protein bL28m

2

1

High-throughput

0.606

High

1103036

CENPR
Centromere protein R

2

1

High-throughput

0.606

High

1228895

ZFY26
Zinc finger FYVE domain-containing protein 26

2

3

High-throughput

0.606

High

1240826

ZN343
Zinc finger protein 343

2

1

High-throughput

0.606

High

1244653

GASP3
G protein-coupled receptor associated sorting protein 3

2

2

High-throughput

0.606

High

1253097

ZN620
Zinc finger protein 620

2

1

High-throughput

0.606

High

1386979

GASP2
G-protein coupled receptor-associated sorting protein 2

2

2

High-throughput

0.606

High

1387863

ZBT10
Zinc finger and BTB domain-containing protein 10

2

1

High-throughput

0.606

High

1402065

TRIB3
Tribbles homolog 3

2

12

High-throughput

0.606

High

1407435

EPAS1
Endothelial PAS domain-containing protein 1

2

12

High-throughput

0.606

High

1437020

ZN408
Zinc finger protein 408

2

1

High-throughput

0.606

High

1437846

CLSPN
Claspin

2

1

Small-scale

0.596

High

298637

RAD17
Cell cycle checkpoint protein RAD17

2

9

Small-scale

0.589

High

822914

VHL
von Hippel-Lindau disease tumor suppressor

1

3

Small-scale

0.586

High

155371

CDKA1
Cyclin-dependent kinase 2-associated protein 1

2

0

High-throughput

0.580

High

269423

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

341223

VATG2
V-type proton ATPase subunit G 2

2

0

High-throughput

0.580

High

353635

AGR2
Anterior gradient protein 2 homolog

2

0

High-throughput

0.580

High

619274

TNNI1
Troponin I, slow skeletal muscle

2

0

High-throughput

0.580

High

1218559

IKBP1
Interleukin-1 receptor-associated kinase 1-binding protein 1

2

0

High-throughput

0.580

High

1231817

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

0

High-throughput

0.580

High

1244166

TT23L
Tetratricopeptide repeat protein 23-like

2

0

High-throughput

0.580

High

1420704

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

2

0

High-throughput

0.580

High

1430146

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

279235

ULK1
Serine/threonine-protein kinase ULK1

1

17

Small-scale

0.578

High

1402092

CRML
Protein cramped-like

2

1

High-throughput

0.574

High

221199

SPY2
Protein sprouty homolog 2

1

2

High-throughput

0.573

High

560931

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

1

High-throughput

0.573

High

848952

MAGAB
Melanoma-associated antigen 11

1

2

High-throughput

0.573

High

1109684

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

13

Small-scale

0.561

High

1161269

MK06
Mitogen-activated protein kinase 6

1

9

Small-scale

0.561

High

1161448

HIF1A
Hypoxia-inducible factor 1-alpha

1

12

Small-scale

0.561

High

1395434

NEUL4
Neuralized-like protein 4

2

4

Small-scale

0.558

High

896700

ASCL1
Achaete-scute homolog 1

2

6

High-throughput

0.553

High

948254

MCCD1
Mitochondrial coiled-coil domain protein 1

2

1

High-throughput

0.553

High

960664

HAND2
Heart- and neural crest derivatives-expressed protein 2

2

4

High-throughput

0.553

High

1044717

ARI5A
AT-rich interactive domain-containing protein 5A

2

2

High-throughput

0.553

High

1177921

RSPO4
R-spondin-4

2

1

High-throughput

0.553

High

1210151

VAX1
Ventral anterior homeobox 1

2

3

High-throughput

0.553

High

1359997

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

2

High-throughput

0.553

High

1402454

CCNL2
Cyclin-L2

2

3

High-throughput

0.553

High

1416850

C1QT2
Complement C1q tumor necrosis factor-related protein 2

2

3

High-throughput

0.553

High

1419207

PBX4
Pre-B-cell leukemia transcription factor 4

2

3

High-throughput

0.553

High

1250061

WDR82
WD repeat-containing protein 82

1

12

Small-scale

0.553

High

128085

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

9

High-throughput

0.536

High

128344

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

5

High-throughput

0.536

High

176002

N4BP3
NEDD4-binding protein 3

1

20

High-throughput

0.536

High

284631

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.536

High

541139

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

583907

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

14

High-throughput

0.536

High

890420

NU153
Nuclear pore complex protein Nup153

1

13

High-throughput

0.536

High

906618

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

8

High-throughput

0.536

High

920383

PLK1
Serine/threonine-protein kinase PLK1

1

17

High-throughput

0.536

High

949467

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

High-throughput

0.536

High

1136623

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

9

High-throughput

0.536

High

1143311

PLEC
Plectin

1

9

High-throughput

0.536

High

1186337

MA7D1
MAP7 domain-containing protein 1

1

8

High-throughput

0.536

High

1235042

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.536

High

1383189

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.536

High

1385451

SYTL4
Synaptotagmin-like protein 4

1

2

High-throughput

0.536

High

1405788

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

2

High-throughput

0.536

High

1406307

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

2

High-throughput

0.536

High

1417837

PDIP3
Polymerase delta-interacting protein 3

1

1

High-throughput

0.536

High

1417914

DUS16
Dual specificity protein phosphatase 16

1

7

High-throughput

0.536

High

1435253

TM134
Transmembrane protein 134

1

1

High-throughput

0.536

High

458518

ADRB2
Beta-2 adrenergic receptor

2

3

Small-scale

0.533

High

1272146

BEND5
BEN domain-containing protein 5

1

1

High-throughput

0.523

High

1452939

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

2

High-throughput

0.515

High

1234801

ZN770
Zinc finger protein 770

1

0

High-throughput

0.513

High

572756

PA2GA
Phospholipase A2, membrane associated

1

5

Small-scale

0.501

High

605859

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

10

Small-scale

0.501

High

1339861

PJA1
E3 ubiquitin-protein ligase Praja-1

1

5

High-throughput

0.501

High

1458587

SPAST
Spastin

1

6

Small-scale

0.501

High

653670

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.489

High

711605

NK3R
Neuromedin-K receptor

1

4

High-throughput

0.489

High

769808

RFC4
Replication factor C subunit 4

1

7

High-throughput

0.489

High

769924

RFC2
Replication factor C subunit 2

1

8

High-throughput

0.489

High

829291

RFC3
Replication factor C subunit 3

1

7

High-throughput

0.489

High

1214833

ATD3B
ATPase family AAA domain-containing protein 3B

1

10

High-throughput

0.489

High

1350668

ALAT2
Alanine aminotransferase 2

1

2

High-throughput

0.489

High

1432708

KCNF1
Voltage-gated potassium channel regulatory subunit KCNF1

1

1

High-throughput

0.489

High

386377

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

17

High-throughput

0.481

High

516078

SRG2B
SLIT-ROBO Rho GTPase-activating protein 2B

1

6

High-throughput

0.481

High

894257

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.481

High

1460005

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

1

Small-scale

0.481

High

1490805

KLH20
Kelch-like protein 20

1

6

High-throughput

0.481

High

905712

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

Small-scale

0.480

High

169166

ML12B
Myosin regulatory light chain 12B

1

4

Small-scale

0.479

High

170442

AURKA
Aurora kinase A

1

20

Small-scale

0.479

High

213282

CP110
Centriolar coiled-coil protein of 110 kDa

1

1

Small-scale

0.479

High

318419

MYO1D
Unconventional myosin-Id

1

19

Small-scale

0.479

High

350191

SNAI1
Zinc finger protein SNAI1

1

11

Small-scale

0.479

High

390224

ALBU
Albumin

1

2

Small-scale

0.479

High

424288

S10A8
Protein S100-A8

1

10

Small-scale

0.479

High

445098

S10A9
Protein S100-A9

1

11

Small-scale

0.479

High

447898

TPM3
Tropomyosin alpha-3 chain

1

4

Small-scale

0.479

High

456292

CATD
Cathepsin D

1

2

Small-scale

0.479

High

457787

TBB5
Tubulin beta chain

1

12

Small-scale

0.479

High

528374

THIO
Thioredoxin

1

1

Small-scale

0.479

High

535696

BIP
Endoplasmic reticulum chaperone BiP

1

10

Small-scale

0.479

High

553100

PIP
Prolactin-inducible protein

1

1

Small-scale

0.479

High

577931

PLAK
Junction plakoglobin

1

20

Small-scale

0.479

High

587843

DESP
Desmoplakin

1

17

Small-scale

0.479

High

686532

RL13
Large ribosomal subunit protein eL13

1

4

Small-scale

0.479

High

724656

S10A7
Protein S100-A7

1

11

Small-scale

0.479

High

732740

ARRB2
Beta-arrestin-2

1

4

Small-scale

0.479

High

765140

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

773092

MYH9
Myosin-9

1

16

Small-scale

0.479

High

773310

MYH10
Myosin-10

1

16

Small-scale

0.479

High

788271

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

Small-scale

0.479

High

801588

HSPA9
Stress-70 protein, mitochondrial

1

19

Small-scale

0.479

High

810468

RL3
Large ribosomal subunit protein uL3

1

3

Small-scale

0.479

High

860647

RS5
Small ribosomal subunit protein uS7

1

2

Small-scale

0.479

High

861024

RS10
Small ribosomal subunit protein eS10

1

3

Small-scale

0.479

High

895168

EMD
Emerin

1

1

High-throughput

0.479

High

931171

HSP72
Heat shock-related 70 kDa protein 2

1

8

Small-scale

0.479

High

951536

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

952673

MYL6
Myosin light polypeptide 6

1

6

Small-scale

0.479

High

953202

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.479

High

970183

RS16
Small ribosomal subunit protein uS9

1

3

Small-scale

0.479

High

973002

RS18
Small ribosomal subunit protein uS13

1

2

Small-scale

0.479

High

976039

RL7A
Large ribosomal subunit protein eL8

1

4

Small-scale

0.479

High

1010736

DCD
Dermcidin

1

2

Small-scale

0.479

High

1028914

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

12

Small-scale

0.479

High

1036822

DSG1
Desmoglein-1

1

5

Small-scale

0.479

High

1051340

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.479

High

1057481

SOX4
Transcription factor SOX-4

1

8

Small-scale

0.479

High

1090987

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.479

High

1108300

SQSTM
Sequestosome-1

1

12

Small-scale

0.479

High

1111754

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1117535

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

11

Small-scale

0.479

High

1163305

H2B2E
Histone H2B type 2-E

1

20

Small-scale

0.479

High

1204048

FILA2
Filaggrin-2

1

12

Small-scale

0.479

High

1220902

RN123
E3 ubiquitin-protein ligase RNF123

1

15

High-throughput

0.479

High

1224792

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.479

High

1259588

TBA1A
Tubulin alpha-1A chain

1

10

Small-scale

0.479

High

1295733

HORN
Hornerin

1

13

Small-scale

0.479

High

1334068

DHB11
Estradiol 17-beta-dehydrogenase 11

1

3

High-throughput

0.479

High

1359468

LMO7
LIM domain only protein 7

1

17

Small-scale

0.479

High

1399472

SPB12
Serpin B12

1

4

Small-scale

0.479

High

1404289

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

1414510

DERL1
Derlin-1

1

4

High-throughput

0.479

High

1430007

SHRPN
Sharpin

1

5

Small-scale

0.479

High

1447127

XPP3
Xaa-Pro aminopeptidase 3

1

1

Small-scale

0.479

High

1450142

OTULL
Inactive ubiquitin thioesterase OTULINL

1

3

High-throughput

0.479

High

1452731

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.479

High

1460313

XPO7
Exportin-7

1

7

High-throughput

0.479

High

46625

A0A286YEY3
SLIT-ROBO Rho GTPase activating protein 2B

1

5

High-throughput

0.470

High

1200616

Q53XM7
VAMP

1

6

High-throughput

0.470

High

1232648

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.470

High

1412203

Q9BS75
Kelch-like protein 20

1

6

High-throughput

0.470

High

69417

WASH1
WASH complex subunit 1

1

0

High-throughput

0.460

High

370377

CYTA
Cystatin-A

1

0

Small-scale

0.458

High

423718

ARGI1
Arginase-1

1

0

Small-scale

0.458

High

1062320

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

0

Small-scale

0.458

High

1213862

KPRP
Keratinocyte proline-rich protein

1

0

Small-scale

0.458

High

1387180

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

Small-scale

0.458

High

256707

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

5

Small-scale

0.437

High

369282

ANT3
Antithrombin-III

1

4

Small-scale

0.437

High

472230

ADRB1
Beta-1 adrenergic receptor

1

6

Small-scale

0.437

High

595907

H13
Histone H1.3

1

10

Small-scale

0.437

High

671876

ZA2G
Zinc-alpha-2-glycoprotein

1

1

Small-scale

0.437

High

680546

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

8

Small-scale

0.437

High

980569

H4
Histone H4

1

8

Small-scale

0.437

High

1109536

ATR
Serine/threonine-protein kinase ATR

1

6

Small-scale

0.437

High

1149570

CDSN
Corneodesmosin

1

1

Small-scale

0.437

High

1162930

H2A2C
Histone H2A type 2-C

1

20

Small-scale

0.437

High

1368988

IOD2
Type II iodothyronine deiodinase

1

1

Small-scale

0.437

High

1462009

ALK
ALK tyrosine kinase receptor

1

14

High-throughput

0.437

High

1228826

Q68DG8
Uncharacterized protein DKFZp781N1423

1

5

High-throughput

0.407

High

1273831

NIPA1
Magnesium transporter NIPA1

1

2

High-throughput

0.407

High

1398026

MF14A
Hippocampus abundant transcript 1 protein

1

3

High-throughput

0.407

High

1461547

S39AA
Zinc transporter ZIP10

1

1

High-throughput

0.407

High

1330700

BEND7
BEN domain-containing protein 7

3

0

High-throughput

0.352

High

1331166

SAM12
Sterile alpha motif domain-containing protein 12

2

0

High-throughput

0.316

High

292782

RENR
Renin receptor

1

0

High-throughput

0.279

Low

1459711

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

948032

DEF1
Neutrophil defensin 1

1

0

Small-scale

0.249

Low

1248756

SBSN
Suprabasin

1

0

Small-scale

0.249

Low

1340050

OR1L3
Olfactory receptor 1L3

1

0

Small-scale

0.249

Low

1445830

BPIA1
BPI fold-containing family A member 1

1

0

Small-scale

0.249

Low

1454026

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025