HitPredict

Interactor 1: CCL2 (P13500)
C-C motif chemokine 2 (HC11) (Monocyte chemoattractant protein 1) (Monocyte chemotactic and activating factor) (MCAF) (Monocyte chemotactic protein 1) (MCP-1) (Monocyte secretory protein JE) (Small-inducible cytokine A2)
Gene: CCL2

Interactor 2: ACKR4 (Q9NPB9)
Atypical chemokine receptor 4 (C-C chemokine receptor type 11) (C-C CKR-11) (CC-CKR-11) (CCR-11) (CC chemokine receptor-like 1) (CCRL1) (CCX CKR)
Gene: ACKR4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	10734104
Identification Methods	biochemical, competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 99 Hs			1 350
+	Hs
		1305163 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR4_HUMAN (1-350): 4.66e-89: 272: 100.00
+	Hs
		849619 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		561732 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		526564 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR3_HUMAN (7-349): 1.94e-86: 266: 29.23
+	Hs
		134400 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134356 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		134373 CCL8_HUMAN (1-98): 1.39e-33: 113: 69.39		ACKR2_HUMAN (2-332): 5.17e-81: 253: 32.15
+	Hs
		783833 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR2_HUMAN (1-327): 1.37e-72: 231: 29.39
+	Hs
		830629 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CXCR3_HUMAN (2-349): 7.54e-71: 227: 29.63
+	Hs
		849654 CCL13_HUMAN (1-99): 1.97e-37: 123: 64.65		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Mm
		500590 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR1_MOUSE (10-349): 4.08e-73: 232: 30.64
+	Mm
		486358 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		CCR2_MOUSE (1-349): 7.53e-71: 227: 28.69
+	Hs
		561733 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Mm
		500591 CCL3_MOUSE (1-94): 1.78e-34: 115: 37.23		CCR3_MOUSE (30-348): 1.44e-71: 228: 31.39
+	Hs
		561728 CL3L1_HUMAN (1-94): 2.21e-35: 117: 38.30		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		526565 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR5_HUMAN (12-349): 4.53e-71: 227: 30.23
+	Hs
		526560 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		686635 CCL8_HUMAN (1-98): 1.39e-33: 113: 69.39		CCR1_HUMAN (30-344): 8.33e-71: 226: 30.79
+	Hs
		526561 CCL4_HUMAN (1-93): 1.25e-34: 115: 35.48		CXCR5_HUMAN (1-350): 1.49e-64: 210: 26.45
+	Mm
		139696 CCL2_MOUSE (1-94): 1.45e-35: 119: 54.26		ACKR2_MOUSE (22-314): 1.65e-39: 145: 31.37