HitPredict

Interactor 1: MYH6 (P13533)
Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)
Gene: MYH6

Interactor 2: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1939 Hs			1 826
+	Hs
		649050 MYH10_HUMAN (26-1928): 0: 1015: 40.10		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		1085714 MYH2_HUMAN (1067-1939): 8.69e-56: 217: 15.24		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		522551 MYH1_HUMAN (1102-1939): 1.21e-51: 204: 16.43		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		1085739 MYH4_HUMAN (1264-1939): 3.3e-45: 182: 15.09		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Hs
		502916 MYH3_HUMAN (730-1405): 7.93e-31: 135: 14.90		HIF1A_HUMAN (1-826): 0: 741: 100.00
+	Dm
		1096484 MYSN_DROME (860-1939): 4.27e-63: 241: 18.82		SIMA_DROME (4-722): 1.28e-95: 329: 25.42
+	Hs
		649049 MYH9_HUMAN (1074-1939): 5.95e-55: 214: 16.42		ARNT_HUMAN (7-652): 5.14e-103: 338: 17.06
+	Hs
		725093 MYH9_HUMAN (1074-1939): 5.95e-55: 214: 16.42		NCOA3_HUMAN (1-746): 4.42e-98: 335: 15.31