Protein: TXNL1
Thioredoxin-like protein 1 (32 kDa thioredoxin-related protein)

Gene: TXNL1
Organism: Homo sapiens
Interactions: 150
UniProt ID: O43396

Gene Ontology (top 5):
GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0015035 - protein-disulfide reductase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

137869

PSDE
26S proteasome non-ATPase regulatory subunit 14

3

9

Small-scale

0.853

High

215279

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

3

Small-scale

0.754

High

215259

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

2

High-throughput

0.618

High

215315

PRP8
Pre-mRNA-processing-splicing factor 8

1

5

High-throughput

0.618

High

215330

DNJ5G
DnaJ homolog subfamily C member 5G

1

8

High-throughput

0.618

High

215349

TXNIP
Thioredoxin-interacting protein

1

7

Small-scale

0.618

High

215276

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

4

High-throughput

0.611

High

215251

PRS6A
26S proteasome regulatory subunit 6A

2

18

Small-scale

0.595

High

215221

KDM1A
Lysine-specific histone demethylase 1A

2

2

High-throughput

0.584

High

215244

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

5

Small-scale

0.584

High

215263

CCNF
Cyclin-F

2

7

High-throughput

0.584

High

215302

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

High-throughput

0.575

High

215270

PSB2
Proteasome subunit beta type-2

2

5

Small-scale

0.571

High

215298

UBE3A
Ubiquitin-protein ligase E3A

2

10

Small-scale

0.571

High

215327

DJC22
DnaJ homolog subfamily C member 22

1

3

High-throughput

0.553

High

215351

DNJC4
DnaJ homolog subfamily C member 4

1

20

High-throughput

0.553

High

215246

TAU
Microtubule-associated protein tau

2

11

High-throughput

0.552

High

215265

PRS6B
26S proteasome regulatory subunit 6B

1

3

High-throughput

0.536

High

215287

PRS4
26S proteasome regulatory subunit 4

1

2

High-throughput

0.536

High

215364

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

11

High-throughput

0.536

High

215238

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

215249

AATC
Aspartate aminotransferase, cytoplasmic

1

2

High-throughput

0.515

High

215283

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.513

High

215284

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

215356

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.486

High

122673

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.479

High

136030

PLK4
Serine/threonine-protein kinase PLK4

1

6

Small-scale

0.479

High

215222

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

12

High-throughput

0.479

High

215223

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

215224

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

215225

MTX2
Metaxin-2

1

2

High-throughput

0.479

High

215226

EED
Polycomb protein EED

1

16

High-throughput

0.479

High

215227

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

14

High-throughput

0.479

High

215229

MFN2
Mitofusin-2

1

2

High-throughput

0.479

High

215230

PCNT
Pericentrin

1

1

High-throughput

0.479

High

215232

LATS1
Serine/threonine-protein kinase LATS1

1

1

High-throughput

0.479

High

215233

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

215237

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

215239

ISG15
Ubiquitin-like protein ISG15

1

5

Small-scale

0.479

High

215240

K1C18
Keratin, type I cytoskeletal 18

1

1

High-throughput

0.479

High

215241

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

215242

CLCA
Clathrin light chain A

1

2

High-throughput

0.479

High

215243

CLCB
Clathrin light chain B

1

2

High-throughput

0.479

High

215245

ANDR
Androgen receptor

1

12

High-throughput

0.479

High

215247

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

215248

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

215250

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

16

High-throughput

0.479

High

215255

PSA1
Proteasome subunit alpha type-1

1

4

Small-scale

0.479

High

215256

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

215260

CTNA1
Catenin alpha-1

1

3

Small-scale

0.479

High

215261

CTNB1
Catenin beta-1

1

4

High-throughput

0.479

High

215264

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

215268

CENPA
Histone H3-like centromeric protein A

1

3

High-throughput

0.479

High

215271

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.479

High

215272

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.479

High

215273

BAP31
B-cell receptor-associated protein 31

1

8

High-throughput

0.479

High

215274

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

215275

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.479

High

215277

RD23A
UV excision repair protein RAD23 homolog A

1

6

Small-scale

0.479

High

215278

RD23B
UV excision repair protein RAD23 homolog B

1

7

High-throughput

0.479

High

215280

AFAD
Afadin

1

13

High-throughput

0.479

High

215281

IF6
Eukaryotic translation initiation factor 6

1

1

High-throughput

0.479

High

215282

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

215285

ACTZ
Alpha-centractin

1

7

High-throughput

0.479

High

215286

RND3
Rho-related GTP-binding protein RhoE

1

6

High-throughput

0.479

High

215288

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

215289

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

215291

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

13

High-throughput

0.479

High

215292

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

215293

AP2B1
AP-2 complex subunit beta

1

3

High-throughput

0.479

High

215294

EF1A1
Elongation factor 1-alpha 1

1

2

Small-scale

0.479

High

215296

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.479

High

215297

EXOSX
Exosome complex component 10

1

2

High-throughput

0.479

High

215300

TRI26
Tripartite motif-containing protein 26

1

8

Small-scale

0.479

High

215301

RFA4
Replication protein A 30 kDa subunit

1

6

High-throughput

0.479

High

215303

DCTN1
Dynactin subunit 1

1

1

High-throughput

0.479

High

215305

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

7

High-throughput

0.479

High

215308

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

215310

DDI2
Protein DDI1 homolog 2

1

6

High-throughput

0.479

High

215311

CBPC6
Cytosolic carboxypeptidase 6

1

1

Small-scale

0.479

High

215312

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

215313

CP135
Centrosomal protein of 135 kDa

1

2

High-throughput

0.479

High

215314

A16L1
Autophagy-related protein 16-1

1

19

High-throughput

0.479

High

215317

SAS6
Spindle assembly abnormal protein 6 homolog

1

3

High-throughput

0.479

High

215318

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

215320

RHOU
Rho-related GTP-binding protein RhoU

1

6

High-throughput

0.479

High

215321

DET1
DET1 homolog

1

3

High-throughput

0.479

High

215322

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

215323

DYR2
Dihydrofolate reductase 2, mitochondrial

1

3

High-throughput

0.479

High

215324

GOLI
E3 ubiquitin-protein ligase RNF130

1

17

High-throughput

0.479

High

215328

WDTC1
WD and tetratricopeptide repeats protein 1

1

17

High-throughput

0.479

High

215332

NUP43
Nucleoporin Nup43

1

17

High-throughput

0.479

High

215333

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

215334

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

215336

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.479

High

215337

TOPB1
DNA topoisomerase 2-binding protein 1

1

4

High-throughput

0.479

High

215339

RND1
Rho-related GTP-binding protein Rho6

1

7

High-throughput

0.479

High

215342

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

16

High-throughput

0.479

High

215344

CK5P2
CDK5 regulatory subunit-associated protein 2

1

5

High-throughput

0.479

High

215352

PXMP2
Peroxisomal membrane protein 2

1

3

High-throughput

0.479

High

215353

PIHD1
PIH1 domain-containing protein 1

1

4

High-throughput

0.479

High

215354

WSB2
WD repeat and SOCS box-containing protein 2

1

14

High-throughput

0.479

High

215358

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

215360

MYO6
Unconventional myosin-VI

1

2

High-throughput

0.479

High

215361

FBW1A
F-box/WD repeat-containing protein 1A

1

13

High-throughput

0.479

High

63912

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

215254

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

215258

TMOD1
Tropomodulin-1

1

0

High-throughput

0.458

High

215290

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

215304

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

0

High-throughput

0.458

High

215306

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

215307

ADRM1
Proteasomal ubiquitin receptor ADRM1

1

0

High-throughput

0.458

High

215319

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

215338

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

215347

SHRPN
Sharpin

1

0

Small-scale

0.458

High

215359

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

215235

PRIO
Major prion protein

1

3

High-throughput

0.445

High

104885

APRIO
Alternative prion protein

1

7

High-throughput

0.437

High

215220

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.437

High

215228

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.437

High

215231

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.437

High

215234

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

4

High-throughput

0.437

High

215236

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.437

High

215253

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

3

High-throughput

0.437

High

215257

CALX
Calnexin

1

20

High-throughput

0.437

High

215262

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

215267

LMAN1
Protein ERGIC-53

1

4

High-throughput

0.437

High

215299

GOGA2
Golgin subfamily A member 2

1

7

High-throughput

0.437

High

215316

RHDF2
Inactive rhomboid protein 2

1

3

High-throughput

0.437

High

215325

DHX40
Probable ATP-dependent RNA helicase DHX40

1

1

High-throughput

0.437

High

215326

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

215335

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

215341

PF21A
PHD finger protein 21A

1

9

High-throughput

0.437

High

215343

RHOV
Rho-related GTP-binding protein RhoV

1

5

High-throughput

0.437

High

215345

RHBT2
Rho-related BTB domain-containing protein 2

1

8

High-throughput

0.437

High

215348

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

6

High-throughput

0.437

High

215350

IFG15
Torsin-1A-interacting protein 2, isoform IFRG15

1

1

High-throughput

0.437

High

215355

MTCH1
Mitochondrial carrier homolog 1

1

5

High-throughput

0.437

High

215362

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

215363

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.437

High

215269

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.408

High

215252

SDC1
Syndecan-1

1

0

High-throughput

0.279

Low

215295

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

215309

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

215329

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

215331

WFDC9
Protein WFDC9

1

0

High-throughput

0.279

Low

215266

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

215340

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

215346

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.249

Low

215357

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025