HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: K1C10 (P13645)
Keratin, type I cytoskeletal 10 (Cytokeratin-10) (CK-10) (Keratin-10) (K10)
Gene: KRT10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31324722, 22038833
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0009986 - cell surface GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Hs			1 584
+	Hs
		529011 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C17_HUMAN (140-456): 6.22e-150: 440: 70.03
+	Hs
		359298 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C14_HUMAN (144-457): 1.33e-144: 427: 69.43
+	Hs
		528449 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C13_HUMAN (135-471): 4.47e-144: 425: 63.50
+	Hs
		444998 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C16_HUMAN (142-456): 9.28e-143: 423: 67.62
+	Hs
		529151 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1H1_HUMAN (139-464): 3.37e-140: 414: 53.68
+	Hs
		444303 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C19_HUMAN (140-456): 2.13e-136: 404: 65.30
+	Hs
		529194 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C24_HUMAN (141-494): 8e-130: 392: 64.17
+	Hs
		528674 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C9_HUMAN (141-455): 3.9e-117: 362: 57.14
+	Hs
		280490 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KT33A_HUMAN (140-456): 7.26e-117: 354: 55.94
+	Hs
		529118 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KT33B_HUMAN (140-456): 4.02e-115: 350: 55.31
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (36-543): 5.33e-93: 296: 24.71
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (36-525): 1.25e-90: 289: 24.24
+	Hs
		528963 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT85_HUMAN (37-518): 4.13e-84: 273: 24.70
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (4-543): 1.61e-80: 265: 26.42
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (36-533): 1.34e-75: 250: 22.96
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (2-463): 5.61e-74: 248: 24.84
+	Hs
		528760 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6C_HUMAN (2-463): 1.56e-73: 247: 24.84
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (2-463): 1.75e-72: 244: 25.05
+	Hs
		528450 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C5_HUMAN (4-463): 5.63e-70: 238: 23.14
+	Hs
		529332 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C74_HUMAN (53-533): 7.48e-70: 236: 23.24