Protein: COX5B
Cytochrome c oxidase subunit 5B, mitochondrial (Cytochrome c oxidase polypeptide Vb)

Gene: COX5B
Organism: Homo sapiens
Interactions: 159
UniProt ID: P10606

Gene Ontology (top 5):
GO:0004129 - cytochrome-c oxidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen
GO:0007585 - respiratory gaseous exchange by respiratory system

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

528411

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

5

1

High-throughput

0.912

High

156183

CO72L
Cytochrome c oxidase subunit 7A2-like, mitochondrial

2

3

High-throughput

0.776

High

528410

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

1

High-throughput

0.691

High

528422

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

3

High-throughput

0.691

High

528439

CDR2
Cerebellar degeneration-related protein 2

4

1

High-throughput

0.637

High

528454

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

3

0

Small-scale

0.613

High

528526

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

2

High-throughput

0.604

High

528415

CX6B1
Cytochrome c oxidase subunit 6B1

2

1

High-throughput

0.601

High

528531

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

2

0

High-throughput

0.585

High

217045

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

528413

TRI27
Zinc finger protein RFP

2

0

High-throughput

0.580

High

528434

MCCD1
Mitochondrial coiled-coil domain protein 1

2

0

High-throughput

0.580

High

528406

TAU
Microtubule-associated protein tau

2

0

High-throughput

0.576

High

528409

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

2

0

High-throughput

0.576

High

528417

COX7C
Cytochrome c oxidase subunit 7C, mitochondrial

2

0

High-throughput

0.576

High

528489

SPT20
Spermatogenesis-associated protein 20

2

0

High-throughput

0.576

High

528414

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

3

High-throughput

0.575

High

528449

KT33B
Keratin, type I cuticular Ha3-II

2

2

High-throughput

0.553

High

528468

K1C27
Keratin, type I cytoskeletal 27

2

2

High-throughput

0.553

High

528475

CDR2L
Cerebellar degeneration-related protein 2-like

2

1

High-throughput

0.553

High

528473

DPP9
Dipeptidyl peptidase 9

2

2

High-throughput

0.549

High

528440

MMSA
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial

1

2

High-throughput

0.536

High

528460

DPS1
All trans-polyprenyl-diphosphate synthase PDSS1

1

1

High-throughput

0.536

High

528477

DLP1
All trans-polyprenyl-diphosphate synthase PDSS2

1

1

High-throughput

0.536

High

528419

K1C15
Keratin, type I cytoskeletal 15

1

3

High-throughput

0.523

High

528452

K1H1
Keratin, type I cuticular Ha1

1

2

High-throughput

0.523

High

395377

ESR1
Estrogen receptor

2

2

High-throughput

0.521

High

528420

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

3

High-throughput

0.515

High

278614

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

421377

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.513

High

528412

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

0

High-throughput

0.513

High

528433

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.513

High

528446

TOP3A
DNA topoisomerase 3-alpha

1

0

High-throughput

0.513

High

528447

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.513

High

528461

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

1

0

High-throughput

0.513

High

528476

NDUAB
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11

1

0

High-throughput

0.513

High

528483

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

1

0

High-throughput

0.513

High

528492

CX7B2
Cytochrome c oxidase subunit 7B2, mitochondrial

1

0

High-throughput

0.513

High

528516

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.513

High

528517

RTN4
Reticulon-4

1

0

High-throughput

0.513

High

528520

COXM2
COX assembly mitochondrial protein 2 homolog

1

0

High-throughput

0.513

High

528421

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

0

High-throughput

0.493

High

519685

ANDR
Androgen receptor

1

2

Small-scale

0.481

High

279625

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

292060

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

3

High-throughput

0.479

High

296187

SCO1
Protein SCO1 homolog, mitochondrial

1

1

High-throughput

0.479

High

528443

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

528453

SURF1
Surfeit locus protein 1

1

1

High-throughput

0.479

High

528495

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

528500

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

528501

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

216616

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

348332

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

470820

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

486889

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

528407

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

528437

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

528451

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

528464

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

528469

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.458

High

528496

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

528497

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

528499

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

528503

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

528504

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

528508

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

528511

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

528514

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

528521

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

528491

SP7
Transcription factor Sp7

1

1

High-throughput

0.457

High

528530

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.457

High

423874

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

528416

QCR7
Cytochrome b-c1 complex subunit 7

1

1

High-throughput

0.445

High

528457

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

1

High-throughput

0.445

High

528458

PPCEL
Prolyl endopeptidase-like

1

2

High-throughput

0.445

High

528525

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

4

High-throughput

0.445

High

403774

GCR
Glucocorticoid receptor

1

2

High-throughput

0.437

High

507455

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.437

High

528423

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.437

High

528448

TRI14
Tripartite motif-containing protein 14

1

1

High-throughput

0.437

High

528513

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

485826

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.426

High

528488

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.426

High

528502

THIOM
Thioredoxin, mitochondrial

1

0

High-throughput

0.426

High

528436

S35B1
Solute carrier family 35 member B1

1

1

High-throughput

0.407

High

528490

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

2

High-throughput

0.407

High

528518

S35C2
Solute carrier family 35 member C2

1

1

High-throughput

0.407

High

528532

PKP3
Plakophilin-3

1

1

High-throughput

0.407

High

528425

TRI23
E3 ubiquitin-protein ligase TRIM23

3

0

High-throughput

0.350

High

528462

TASO2
Protein TASOR 2

3

0

High-throughput

0.345

High

528479

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.334

High

154931

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.327

High

528523

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.327

High

158719

BORG1
Cdc42 effector protein 2

2

0

High-throughput

0.316

High

299038

FLOT1
Flotillin-1

2

0

High-throughput

0.316

High

528424

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

2

0

High-throughput

0.316

High

528441

ARI5A
AT-rich interactive domain-containing protein 5A

2

0

High-throughput

0.316

High

528442

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.316

High

528459

RBM48
RNA-binding protein 48

2

0

High-throughput

0.316

High

528467

DOK3
Docking protein 3

2

0

High-throughput

0.316

High

528470

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

528474

F228A
Protein FAM228A

2

0

High-throughput

0.316

High

528486

SLAI1
SLAIN motif-containing protein 1

2

0

High-throughput

0.316

High

528506

TEX12
Testis-expressed protein 12

2

0

High-throughput

0.316

High

528515

PKHF2
Pleckstrin homology domain-containing family F member 2

2

0

High-throughput

0.316

High

528519

PRDM6
Putative histone-lysine N-methyltransferase PRDM6

2

0

High-throughput

0.316

High

528527

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

0

High-throughput

0.316

High

528528

NUDT5
ADP-sugar pyrophosphatase

2

0

High-throughput

0.316

High

528480

FANCM
Fanconi anemia group M protein

2

0

High-throughput

0.313

High

528529

EPDR1
Mammalian ependymin-related protein 1

2

0

High-throughput

0.313

High

528429

HD
Huntingtin

2

0

High-throughput

0.306

High

528444

TRAF1
TNF receptor-associated factor 1

1

0

High-throughput

0.299

High

528487

PNMA1
Paraneoplastic antigen Ma1

1

0

High-throughput

0.299

High

165891

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

528430

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.279

Low

528435

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.279

Low

528463

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.279

Low

528494

YIPF5
Protein YIPF5

1

0

High-throughput

0.279

Low

528507

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

528509

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

528522

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

528505

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

528481

PRR22
Proline-rich protein 22

1

0

High-throughput

0.251

Low

528533

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

0

High-throughput

0.251

Low

105188

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

169913

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

222665

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

330607

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.249

Low

370143

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

405725

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.249

Low

417910

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

528408

EPB41
Protein 4.1

1

0

High-throughput

0.249

Low

528418

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

528427

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.249

Low

528432

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.249

Low

528438

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.249

Low

528455

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

528478

NELFD
Negative elongation factor C/D

1

0

High-throughput

0.249

Low

528482

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

528484

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

528485

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

528510

ATG5
Autophagy protein 5

1

0

Small-scale

0.249

Low

528524

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

469404

ELNE
Neutrophil elastase

1

0

Small-scale

0.238

Low

528512

SAV1
Protein salvador homolog 1

1

0

Small-scale

0.238

Low

344076

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

351199

MOT3
Monocarboxylate transporter 3

1

0

High-throughput

0.232

Low

528426

SPB5
Serpin B5

1

0

High-throughput

0.232

Low

528428

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

528431

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

0

High-throughput

0.232

Low

528445

SBP1
Methanethiol oxidase

1

0

High-throughput

0.232

Low

528450

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.232

Low

528456

S35G1
Solute carrier family 35 member G1

1

0

High-throughput

0.232

Low

528465

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

528466

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.232

Low

528471

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

528472

DSG4
Desmoglein-4

1

0

High-throughput

0.232

Low

528493

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.232

Low

528498

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025