HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: CAN2 (P17655)
Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain large polypeptide L2) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)
Gene: CAPN2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	26618866, 31324722, 29924966
Identification Methods	affinity chromatography technology, pull down, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019899 - enzyme binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 700
+	Hs
		427833 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CAN1_HUMAN (3-700): 0: 915: 62.20
+	Hs
		385833 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CPNS1_HUMAN (498-700): 1.57e-56: 195: 42.86
+	Hs
		484052 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CALM3_HUMAN (515-604): 3.65e-13: 69.3: 18.68