Protein: COX4
Cytochrome c oxidase subunit 4, mitochondrial (Cytochrome c oxidase polypeptide IV)

Gene: COX4
Organism: Saccharomyces cerevisiae S288C
Interactions: 165
UniProt ID: P04037

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360309

COX1
Cytochrome c oxidase subunit 1

7

4

Small-scale

0.953

High

360762

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

5

1

Small-scale

0.912

High

360626

COX2
Cytochrome c oxidase subunit 2

7

0

Small-scale

0.902

High

399810

COX13
Cytochrome c oxidase subunit 13, mitochondrial

4

1

Small-scale

0.873

High

360814

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

3

1

Small-scale

0.827

High

360846

COX6
Cytochrome c oxidase subunit 6, mitochondrial

2

1

High-throughput

0.754

High

399774

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

8

3

Small-scale

0.743

High

360738

COX3
Cytochrome c oxidase subunit 3

2

0

Small-scale

0.728

High

399787

COX7
Cytochrome c oxidase subunit 7, mitochondrial

2

0

High-throughput

0.716

High

399792

ADT2
ADP,ATP carrier protein 2

5

4

Small-scale

0.712

High

399776

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

7

0

Small-scale

0.705

High

399785

HSP77
Import motor subunit, mitochondrial

4

1

Small-scale

0.692

High

399812

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

4

1

Small-scale

0.689

High

399769

CY1
Cytochrome c1, heme protein, mitochondrial

4

1

Small-scale

0.676

High

399773

COX9
Cytochrome c oxidase subunit 9, mitochondrial

5

0

Small-scale

0.673

High

399819

MIC60
MICOS complex subunit MIC60

4

0

High-throughput

0.657

High

399778

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

4

0

Small-scale

0.648

High

399867

RCF2
Respiratory supercomplex factor 2, mitochondrial

4

0

Small-scale

0.648

High

399878

RCF1
Respiratory supercomplex factor 1, mitochondrial

4

0

Small-scale

0.648

High

399829

GRPE
GrpE protein homolog, mitochondrial

3

0

Small-scale

0.619

High

397557

SCE3
Intron-encoded DNA endonuclease aI3

1

4

High-throughput

0.618

High

397562

SCE2
Intron-encoded DNA endonuclease aI4

1

5

High-throughput

0.618

High

399762

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.618

High

399903

SCE4
Intron-encoded DNA endonuclease aI5 alpha

1

5

High-throughput

0.618

High

399763

COX8
Cytochrome c oxidase subunit 8, mitochondrial

3

0

Small-scale

0.613

High

399822

QCR10
Cytochrome b-c1 complex subunit 10, mitochondrial

3

0

Small-scale

0.613

High

399866

SHY1
Cytochrome oxidase assembly protein SHY1

2

1

Small-scale

0.611

High

357873

CYB
Cytochrome b

2

3

Small-scale

0.595

High

399835

COX14
Cytochrome c oxidase assembly protein COX14

2

0

Small-scale

0.585

High

357796

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

2

1

High-throughput

0.584

High

399775

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

2

2

High-throughput

0.584

High

399841

HSP7E
Heat shock protein SSC3, mitochondrial

2

1

High-throughput

0.584

High

399872

COX12
Cytochrome c oxidase subunit 12, mitochondrial

2

1

High-throughput

0.584

High

399881

YHM2
Citrate/oxoglutarate carrier protein

2

6

High-throughput

0.584

High

399889

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

2

1

Small-scale

0.584

High

399770

TOM70
Mitochondrial import receptor subunit TOM70

2

0

Small-scale

0.569

High

399873

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

0

Small-scale

0.569

High

399809

CACP
Carnitine O-acetyltransferase, mitochondrial

2

0

High-throughput

0.565

High

357743

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

2

0

High-throughput

0.559

High

399796

QCR9
Cytochrome b-c1 complex subunit 9, mitochondrial

2

0

High-throughput

0.559

High

399801

NFS1
Cysteine desulfurase, mitochondrial

2

0

Small-scale

0.559

High

399803

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

2

0

High-throughput

0.559

High

399844

FMP10
Uncharacterized mitochondrial membrane protein FMP10

2

0

High-throughput

0.559

High

399853

COX16
Cytochrome c oxidase assembly protein COX16, mitochondrial

2

0

Small-scale

0.559

High

399859

TOM22
Mitochondrial import receptor subunit TOM22

2

0

High-throughput

0.559

High

399896

COX26
Cytochrome c oxidase subunit 26, mitochondrial

2

0

Small-scale

0.559

High

399899

ISD11
Protein ISD11

2

0

Small-scale

0.559

High

399884

STE23
A-factor-processing enzyme

1

1

Small-scale

0.501

High

399857

BXI1
Bax inhibitor 1

1

0

Small-scale

0.493

High

399795

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.486

High

357682

CYC1
Cytochrome c isoform 1

1

1

High-throughput

0.479

High

357720

CYC7
Cytochrome c isoform 2

1

1

High-throughput

0.479

High

367344

CISY1
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

397501

MBI2
Cytochrome b mRNA maturase bI2

1

4

High-throughput

0.479

High

397552

AI2M
Putative COX1/OXI3 intron 2 protein

1

4

High-throughput

0.479

High

397565

MBI4
Intron-encoded RNA maturase bI4

1

4

High-throughput

0.479

High

399764

ADT1
ADP,ATP carrier protein 1

1

4

High-throughput

0.479

High

399768

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

399779

CISY2
Citrate synthase, peroxisomal

1

2

High-throughput

0.479

High

399780

ATPO
ATP synthase subunit 5, mitochondrial

1

1

High-throughput

0.479

High

399790

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

399791

ADT3
ADP,ATP carrier protein 3

1

4

High-throughput

0.479

High

399797

MPCP
Mitochondrial phosphate carrier protein

1

3

High-throughput

0.479

High

399799

SCO1
Protein SCO1, mitochondrial

1

1

High-throughput

0.479

High

399806

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

2

High-throughput

0.479

High

399808

FMT
Methionyl-tRNA formyltransferase, mitochondrial

1

1

High-throughput

0.479

High

399813

PREP
Presequence protease, mitochondrial

1

1

High-throughput

0.479

High

399814

SFC1
Succinate/fumarate mitochondrial transporter

1

7

High-throughput

0.479

High

399825

TXTP
Tricarboxylate transport protein

1

6

High-throughput

0.479

High

399833

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

5

High-throughput

0.479

High

399838

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

1

High-throughput

0.479

High

399846

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

2

High-throughput

0.479

High

399847

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

1

High-throughput

0.479

High

399850

PHB1
Prohibitin-1

1

1

High-throughput

0.479

High

399858

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.479

High

399860

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

399862

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.479

High

399876

ODC1
Mitochondrial 2-oxodicarboxylate carrier 1

1

6

High-throughput

0.479

High

399882

HFD1
Fatty aldehyde dehydrogenase HFD1

1

2

High-throughput

0.479

High

399888

NDH2
External NADH-ubiquinone oxidoreductase 2, mitochondrial

1

2

High-throughput

0.479

High

399901

ODC2
Mitochondrial 2-oxodicarboxylate carrier 2

1

4

High-throughput

0.479

High

399902

MBI3
Cytochrome b mRNA maturase bI3

1

3

High-throughput

0.479

High

367200

ATP6
ATP synthase subunit a

1

0

Small-scale

0.458

High

399765

SYWM
Tryptophan--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

399766

VDAC1
Non-selective voltage-gated ion channel 1

1

0

High-throughput

0.458

High

399767

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

399771

ATPA
ATP synthase subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

399772

CBP6
Cytochrome B pre-mRNA-processing protein 6

1

0

High-throughput

0.458

High

399777

NUC1
Mitochondrial nuclease

1

0

High-throughput

0.458

High

399788

PET54
Protein PET54

1

0

High-throughput

0.458

High

399789

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.458

High

399793

COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

1

0

High-throughput

0.458

High

399794

CBP3
Protein CBP3, mitochondrial

1

0

High-throughput

0.458

High

399798

TOM40
Mitochondrial import receptor subunit TOM40

1

0

High-throughput

0.458

High

399800

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.458

High

399802

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

399804

ATP7
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.458

High

399805

MSS51
Protein MSS51, mitochondrial

1

0

Small-scale

0.458

High

399807

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.458

High

399811

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.458

High

399815

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.458

High

399816

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.458

High

399817

MCR1
NADH-cytochrome b5 reductase 2

1

0

High-throughput

0.458

High

399818

MGR3L
Protein MRG3-like

1

0

High-throughput

0.458

High

399820

CBP4
Assembly factor CBP4

1

0

High-throughput

0.458

High

399821

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

399824

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

399827

MBA1
Inner membrane mitoribosome receptor MBA1, mitochondrial

1

0

High-throughput

0.458

High

399830

FYV4
Small ribosomal subunit protein mS41

1

0

High-throughput

0.458

High

399831

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

399832

PT100
Protein PET100, mitochondrial

1

0

High-throughput

0.458

High

399834

PSD1
Phosphatidylserine decarboxylase proenzyme 1, mitochondrial

1

0

High-throughput

0.458

High

399836

TIM17
Mitochondrial import inner membrane translocase subunit TIM17

1

0

High-throughput

0.458

High

399837

CEM1
3-oxoacyl-[acyl-carrier-protein] synthase homolog

1

0

High-throughput

0.458

High

399840

OXA1
Mitochondrial inner membrane protein OXA1

1

0

High-throughput

0.458

High

399843

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

399848

AIM19
Altered inheritance of mitochondria protein 19, mitochondrial

1

0

High-throughput

0.458

High

399849

PUP1
PUP1 protein homolog

1

0

High-throughput

0.458

High

399851

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.458

High

399855

GCST
Aminomethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

399856

ADRO
Probable NADPH:adrenodoxin oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

399861

MIC27
MICOS complex subunit MIC27

1

0

High-throughput

0.458

High

399863

MCY1
Putative mitochondrial cysteine synthase

1

0

High-throughput

0.458

High

399864

TIM21
Mitochondrial import inner membrane translocase subunit TIM21

1

0

Small-scale

0.458

High

399865

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

399869

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

399870

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

399875

MGR2
Protein MGR2

1

0

High-throughput

0.458

High

399879

AIM36
Altered inheritance of mitochondria protein 36, mitochondrial

1

0

High-throughput

0.458

High

399883

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

399885

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.458

High

399886

ATG33
Autophagy-related protein 33

1

0

High-throughput

0.458

High

399887

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.458

High

399890

COQ10
Coenzyme Q-binding protein COQ10, mitochondrial

1

0

High-throughput

0.458

High

399891

MDM38
Mitochondrial distribution and morphology protein 38

1

0

High-throughput

0.458

High

399897

YD381
Uncharacterized mitochondrial outer membrane protein YDR381C-A

1

0

High-throughput

0.458

High

399900

MIC10
MICOS complex subunit MIC10

1

0

High-throughput

0.458

High

380903

H2B1
Histone H2B.1

1

1

High-throughput

0.437

High

381338

H2B2
Histone H2B.2

1

1

High-throughput

0.437

High

399781

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

399782

RL31B
Large ribosomal subunit protein eL31B

1

1

High-throughput

0.437

High

399783

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.437

High

399784

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

2

High-throughput

0.437

High

399839

SNF7
Vacuolar-sorting protein SNF7

1

1

High-throughput

0.437

High

399877

VPS60
Vacuolar protein-sorting-associated protein 60

1

1

Small-scale

0.437

High

399826

HSL7
Protein arginine N-methyltransferase HSL7

2

0

High-throughput

0.307

High

399898

YB255
Uncharacterized protein YBR255C-A

2

0

Small-scale

0.305

High

399874

SKI8
Antiviral protein SKI8

1

0

High-throughput

0.282

High

399893

GIN4
Serine/threonine-protein kinase GIN4

1

0

High-throughput

0.261

Low

154092

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.249

Low

383386

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

399786

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

399828

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.249

Low

399842

IRC22
Increased recombination centers protein 22

1

0

High-throughput

0.249

Low

399852

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

399868

YN8B
UPF0674 endoplasmic reticulum membrane protein YNR021W

1

0

High-throughput

0.249

Low

399871

RL34A
Large ribosomal subunit protein eL34A

1

0

High-throughput

0.249

Low

399880

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

399892

YP063
Uncharacterized protein YPR063C

1

0

High-throughput

0.249

Low

399894

OSH2
Oxysterol-binding protein homolog 2

1

0

High-throughput

0.249

Low

399895

YK023
Uncharacterized protein YKL023C-A

1

0

High-throughput

0.249

Low

399823

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.238

Low

399854

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.238

Low

399845

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025