HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: LEG3 (P17931)
Galectin-3 (Gal-3) (35 kDa lectin) (Carbohydrate-binding protein 35) (CBP 35) (Galactose-specific lectin 3) (Galactoside-binding protein) (GALBP) (IgE-binding protein) (L-31) (Laminin-binding protein) (Lectin L-29) (Mac-2 antigen)
Gene: LGALS3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	17110338
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0009986 - cell surface and 1 others more... GO:0016020 - membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 250
+	Hs
		528846 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LEG4_HUMAN (92-247): 1.84e-45: 156: 30.82
+	Hs
		449169 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LEG1_HUMAN (125-247): 3.18e-43: 144: 28.00
+	Hs
		119130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67
+	Hs
		529457 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PPL13_HUMAN (112-248): 3.08e-39: 134: 27.08
+	Hs
		398162 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LEG2_HUMAN (125-247): 2.72e-38: 132: 30.65
+	Hs
		572294 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00
+	Hs
		179342 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00
+	Hs
		572423 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		LEG3_HUMAN (1-250): 3.29e-96: 283: 100.00
+	Hs
		119206 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67
+	Hs
		119023 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67
+	Hs
		121117 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		LEG8_HUMAN (105-245): 4.74e-39: 139: 36.11
+	Hs
		121056 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		LEG8_HUMAN (105-245): 4.74e-39: 139: 36.11
+	Hs
		179360 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		LEG9B_HUMAN (108-249): 5.78e-38: 137: 37.67
+	Hs
		179365 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		LEG9C_HUMAN (108-249): 6.7e-38: 137: 37.67
+	Hs
		119468 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67
+	Hs
		119024 MRP5_HUMAN (774-1479): 5.77e-53: 207: 13.26		LEG9_HUMAN (108-249): 3.89e-40: 143: 37.67