HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31324722, 17235394, 29924966
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 2647
+	Hs
		261190 CFTR_HUMAN (1-1480): 0: 1031: 100.00		FLNB_HUMAN (28-2647): 0: 2710: 69.63
+	Hs
		529110 CFTR_HUMAN (1-1480): 0: 1031: 100.00		FLNC_HUMAN (32-2647): 0: 1432: 35.96
+	Hs
		528984 CFTR_HUMAN (1-1480): 0: 1031: 100.00		SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62
+	Hs
		528678 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62
+	Hs
		521456 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53
+	Hs
		529029 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ACTN3_HUMAN (30-460): 2.85e-118: 401: 25.28
+	Hs
		211482 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01