Protein: CP51
Lanosterol 14-alpha demethylase CYP51 (EC 1.14.14.154) (Cytochrome P450 51) (Cytochrome P450-14DM) (Cytochrome P450-LIA1) (CYPLI) (Ergosterol biosynthetic protein 11) (Lanosterol C14-C32 lyase) (Sterol 14-alpha demethylase)

Gene: CP51, ERG11
Organism: Saccharomyces cerevisiae S288C
Interactions: 121
UniProt ID: P10614

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006696 - ergosterol biosynthetic process
GO:0008398 - sterol 14-demethylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

528539

CP51
Lanosterol 14-alpha demethylase CYP51

2

12

Small-scale

0.815

High

528543

NCPR
NADPH--cytochrome P450 reductase

1

4

High-throughput

0.698

High

528623

ERG5
C-22 sterol desaturase ERG5

1

12

High-throughput

0.698

High

528607

STE24
CAAX prenyl protease 1

2

1

High-throughput

0.632

High

528612

ERG25
C-4 methylsterol oxidase ERG25

2

3

Small-scale

0.632

High

528566

ERG24
Delta(14)-sterol reductase ERG24

2

2

Small-scale

0.614

High

528591

ERG28
Ergosterol biosynthetic protein 28

2

0

Small-scale

0.609

High

528548

EPT1
Choline/ethanolaminephosphotransferase 1

2

1

High-throughput

0.608

High

528556

LAC1
Ceramide synthase LAC1

2

0

High-throughput

0.605

High

528579

PHO88
SRP-independent targeting protein 3

2

0

High-throughput

0.588

High

528564

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

2

3

Small-scale

0.576

High

528622

ASI1
ERAD-associated E3 ubiquitin-protein ligase ASI1

2

1

Small-scale

0.558

High

528544

CPT1
Cholinephosphotransferase 1

1

1

High-throughput

0.541

High

528545

HNM1
Choline transporter

1

5

High-throughput

0.541

High

528546

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.541

High

528550

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

528552

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

Small-scale

0.541

High

528553

ELO2
Fatty acid elongase 2

1

2

High-throughput

0.541

High

528565

YBT1
ATP-dependent bile acid permease

1

1

High-throughput

0.541

High

528587

SUR2
Sphingolipid C4-hydroxylase SUR2

1

3

High-throughput

0.541

High

528606

SPC1
Signal peptidase complex subunit 1

1

2

High-throughput

0.541

High

528614

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

3

Small-scale

0.541

High

528624

TMEDA
Endoplasmic reticulum vesicle protein 25

1

2

High-throughput

0.541

High

528626

OSH6
Oxysterol-binding protein homolog 6

1

2

High-throughput

0.541

High

528629

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

5

High-throughput

0.541

High

528639

ERP1
Protein ERP1

1

2

High-throughput

0.541

High

528647

SAM3
S-adenosylmethionine permease SAM3

1

4

High-throughput

0.541

High

528650

RTN2
Reticulon-like protein 2

1

5

High-throughput

0.541

High

528651

ERG27
3-keto-steroid reductase ERG27

1

2

Small-scale

0.541

High

427992

CHO2
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.518

High

439497

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.518

High

528547

SEC62
Translocation protein SEC62

1

0

High-throughput

0.518

High

528559

ERG9
Squalene synthase ERG9

1

0

Small-scale

0.518

High

528561

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.518

High

528570

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.518

High

528571

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.518

High

528581

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.518

High

528582

ERG7
Lanosterol synthase ERG7

1

0

Small-scale

0.518

High

528589

SOP4
Protein SOP4

1

0

High-throughput

0.518

High

528596

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.518

High

528599

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.518

High

528600

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.518

High

528601

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.518

High

528604

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.518

High

528605

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

528608

ILM1
Protein ILM1

1

0

High-throughput

0.518

High

528610

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.518

High

528616

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.518

High

528627

SHR3
Secretory component protein SHR3

1

0

High-throughput

0.518

High

528628

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

0

High-throughput

0.518

High

528631

PKR1
V-type ATPase assembly factor PKR1

1

0

High-throughput

0.518

High

528633

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.518

High

528638

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.518

High

528642

ORM2
Protein ORM2

1

0

High-throughput

0.518

High

528643

ARV1
Protein ARV1

1

0

High-throughput

0.518

High

528652

SEY1
Protein SEY1

1

0

High-throughput

0.518

High

528542

DAL5
Allantoate permease

1

2

High-throughput

0.494

High

528567

HXT1
Low-affinity glucose transporter HXT1

1

1

High-throughput

0.494

High

528572

KES1
Oxysterol-binding protein homolog 4

1

2

High-throughput

0.494

High

528573

SIS2
Phosphopantothenoylcysteine decarboxylase subunit SIS2

1

2

High-throughput

0.494

High

528576

CAB3
Coenzyme A biosynthesis protein 3

1

2

High-throughput

0.494

High

528583

COS8
Protein COS8

1

2

High-throughput

0.494

High

528603

COS4
Protein COS4

1

2

High-throughput

0.494

High

528613

YOR1
Oligomycin resistance ATP-dependent permease YOR1

1

2

High-throughput

0.494

High

528617

COS6
Protein COS6

1

2

High-throughput

0.494

High

528644

VHS3
Phosphopantothenoylcysteine decarboxylase subunit VHS3

1

2

High-throughput

0.494

High

528649

TPO4
Polyamine transporter 4

1

3

High-throughput

0.494

High

528620

ASI2
Protein ASI2

1

0

Small-scale

0.493

High

528593

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

4

Small-scale

0.479

High

528595

CYB5
Cytochrome b5

1

5

High-throughput

0.479

High

528609

HLJ1
Protein HLJ1

1

3

High-throughput

0.479

High

528637

RTN1
Reticulon-like protein 1

1

5

Small-scale

0.479

High

528621

ASI3
Probable ERAD-associated E3 ubiquitin-protein ligase ASI1

1

1

Small-scale

0.470

High

528568

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.458

High

528653

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

528636

ERV41
ER-derived vesicles protein ERV41

1

2

High-throughput

0.457

High

528563

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.438

High

528646

FLC1
Flavin carrier protein 1

1

0

High-throughput

0.438

High

528541

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.437

High

528551

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

528558

BMH1
Protein BMH1

1

2

High-throughput

0.437

High

528560

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

528578

ATG8
Autophagy-related protein 8

1

3

High-throughput

0.437

High

528592

IMB4
Importin subunit beta-4

1

1

High-throughput

0.437

High

528630

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.437

High

528641

IMB1
Importin subunit beta-1

1

1

High-throughput

0.437

High

528645

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

528585

ATC2
Calcium-transporting ATPase 2

1

3

High-throughput

0.417

High

392096

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.407

High

509353

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

7

High-throughput

0.407

High

522843

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.407

High

528540

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.407

High

528594

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.407

High

528555

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

0

High-throughput

0.282

High

528557

TRK2
Low-affinity potassium transport protein

1

0

High-throughput

0.282

High

528574

MID2
Cell wall integrity sensor MID2

1

0

High-throughput

0.282

High

528575

MNN4
Mannosyltransferase regulator 4

1

0

High-throughput

0.282

High

528584

SHU1
Suppressor of HU sensitivity involved in recombination protein 1

1

0

High-throughput

0.282

High

528586

SRP14
Signal recognition particle subunit SRP14

1

0

High-throughput

0.282

High

528598

GPX3
Glutathione peroxidase-like peroxiredoxin HYR1

1

0

High-throughput

0.282

High

528611

AVT4
Vacuolar amino acid transporter 4

1

0

High-throughput

0.282

High

528618

TOM7
Mitochondrial import receptor subunit TOM7

1

0

High-throughput

0.282

High

528648

ENG2
Glucan endo-1,3-beta-D-glucosidase 2

1

0

High-throughput

0.282

High

528569

CBS
Cystathionine beta-synthase

1

0

High-throughput

0.269

Low

528549

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

528562

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

528577

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

528588

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

528590

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.249

Low

528597

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

528602

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

528615

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

528619

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

528625

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.249

Low

528632

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

528634

SXM1
Importin beta SMX1

1

0

High-throughput

0.249

Low

528635

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

528640

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

528580

MCFS2
Medium-chain fatty acid ethyl ester synthase/esterase 2

1

0

High-throughput

0.238

Low

528554

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025