HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: KRT85 (P78386)
Keratin, type II cuticular Hb5 (Hair keratin K2.12) (Keratin-85) (K85) (Type II hair keratin Hb5) (Type-II keratin Kb25)
Gene: KRT85

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 507
+	Hs
		444525 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C7_HUMAN (14-445): 2.34e-160: 465: 53.46
+	Hs
		61951 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KR87P_HUMAN (186-415): 1.11e-132: 386: 90.44
+	Hs
		380546 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C1_HUMAN (92-448): 8.37e-123: 375: 54.44
+	Hs
		408988 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C8_HUMAN (46-461): 7.91e-114: 346: 53.61
+	Hs
		529780 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT84_HUMAN (1-506): 2.9e-107: 333: 56.73
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (8-490): 1.97e-103: 320: 82.06
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (7-501): 1.59e-101: 315: 81.65
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (3-437): 4.67e-87: 279: 49.78
+	Mm
		514315 CFTR_MOUSE (1-1468): 0: 957: 78.29		K2C8_MOUSE (95-486): 1.9e-114: 348: 54.08
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (10-507): 6.8e-80: 260: 43.65
+	Hs
		528450 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C5_HUMAN (3-437): 1.8e-75: 250: 48.65
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (1-437): 1.45e-74: 247: 49.48
+	Hs
		528760 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6C_HUMAN (1-437): 4.58e-74: 246: 49.48
+	Hs
		529332 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C74_HUMAN (59-506): 5.92e-73: 242: 45.56
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (90-437): 5.41e-72: 240: 60.00
+	Hs
		529503 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT35_HUMAN (28-482): 1.18e-66: 223: 25.05