HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: DSC1 (Q08554)
Desmocollin-1 (Cadherin family member 1) (Desmosomal glycoprotein 2/3) (DG2/DG3)
Gene: DSC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26618866, 31324722
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 894
+	Hs
		529966 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PCDGH_HUMAN (1-842): 0: 801: 17.96
+	Hs
		529910 CFTR_HUMAN (1-1480): 0: 1031: 100.00		PCDB8_HUMAN (3-792): 0: 760: 17.17
+	Hs
		521697 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CADH1_HUMAN (23-890): 0: 699: 29.13
+	Hs
		528548 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CADH3_HUMAN (9-889): 0: 586: 26.33
+	Hs
		528838 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CAD13_HUMAN (11-677): 0: 571: 31.36
+	Hs
		529095 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DSG2_HUMAN (31-390): 4.92e-21: 101: 17.41