Protein: CBR1
Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)

Gene: CBR1
Organism: Homo sapiens
Interactions: 150
UniProt ID: P16152

Gene Ontology (top 5):
GO:0004090 - carbonyl reductase (NADPH) activity
GO:0005829 - cytosol
GO:0006805 - xenobiotic metabolic process
GO:0008106 - alcohol dehydrogenase (NADP+) activity
GO:0008211 - glucocorticoid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

276075

CBR3
Carbonyl reductase [NADPH] 3

3

12

High-throughput

0.871

High

226438

PRKN
E3 ubiquitin-protein ligase parkin

3

9

High-throughput

0.640

High

368929

ESR1
Estrogen receptor

2

5

Small-scale

0.611

High

528486

CFTR
Cystic fibrosis transmembrane conductance regulator

2

5

High-throughput

0.601

High

556687

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

0

High-throughput

0.585

High

383585

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

2

High-throughput

0.576

High

556581

CBR1
Carbonyl reductase [NADPH] 1

1

11

Small-scale

0.575

High

337880

EGFR
Epidermal growth factor receptor

2

3

Small-scale

0.555

High

556650

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

556587

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.541

High

556590

AGTR1
Type-1 angiotensin II receptor

1

3

High-throughput

0.541

High

556654

RANB9
Ran-binding protein 9

1

5

High-throughput

0.541

High

125967

UPK1A
Uroplakin-1a

1

7

High-throughput

0.536

High

496231

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.536

High

556593

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

556600

NCBP2
Nuclear cap-binding protein subunit 2

1

4

High-throughput

0.536

High

556604

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.536

High

556623

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

556645

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

556667

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

556668

KPCD2
Serine/threonine-protein kinase D2

1

4

High-throughput

0.536

High

556669

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

556674

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.536

High

556657

ZBT18
Zinc finger and BTB domain-containing protein 18

2

2

Small-scale

0.521

High

556599

STA5B
Signal transducer and activator of transcription 5B

1

0

High-throughput

0.518

High

556609

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.518

High

556585

CRCM
Colorectal mutant cancer protein

1

4

High-throughput

0.515

High

58566

DEND3
DENN domain-containing protein 3

1

0

High-throughput

0.513

High

201202

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

537590

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.513

High

556610

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

556614

TXN4A
Thioredoxin-like protein 4A

1

0

High-throughput

0.513

High

556617

CUL1
Cullin-1

1

0

High-throughput

0.513

High

556640

PPHLN
Periphilin-1

1

0

High-throughput

0.513

High

556661

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

174605

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

475313

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

High-throughput

0.501

High

556646

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

556596

5HT2B
5-hydroxytryptamine receptor 2B

1

1

High-throughput

0.494

High

147697

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.493

High

331368

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

4

High-throughput

0.489

High

522536

MYH1
Myosin-1

1

3

High-throughput

0.489

High

556591

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.489

High

556612

SSBP2
Single-stranded DNA-binding protein 2

1

1

High-throughput

0.489

High

556624

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

556627

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

3

High-throughput

0.489

High

556628

Z518A
Zinc finger protein 518A

1

2

High-throughput

0.489

High

556633

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

556636

CDKL3
Cyclin-dependent kinase-like 3

1

5

High-throughput

0.489

High

556639

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.489

High

556641

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

556647

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

556648

FAF2
FAS-associated factor 2

1

1

High-throughput

0.489

High

556659

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.489

High

556662

WAC
WW domain-containing adapter protein with coiled-coil

1

1

High-throughput

0.489

High

556670

S2532
Solute carrier family 25 member 32

1

3

High-throughput

0.489

High

556684

ICAM5
Intercellular adhesion molecule 5

1

2

High-throughput

0.489

High

556685

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.489

High

556595

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.480

High

556663

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.479

High

125137

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

212732

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

354278

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

488117

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.479

High

503379

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

556582

VDAC1
Voltage-dependent anion-selective channel protein 1

1

4

High-throughput

0.479

High

556583

NDKB
Nucleoside diphosphate kinase B

1

3

High-throughput

0.479

High

556586

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

556589

PML
Protein PML

1

3

High-throughput

0.479

High

556598

CDK7
Cyclin-dependent kinase 7

1

3

High-throughput

0.479

High

556601

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

556605

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.479

High

556606

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

556608

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

556611

1433Z
14-3-3 protein zeta/delta

1

6

Small-scale

0.479

High

556616

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

556618

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

556621

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

556660

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

556677

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

3

High-throughput

0.479

High

556680

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

556682

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

556688

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

489898

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

Small-scale

0.460

High

224292

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

298123

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

322143

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

505546

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

556584

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

556597

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

556602

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

556613

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

556619

CUL7
Cullin-7

1

0

High-throughput

0.458

High

556644

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

556675

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

556679

TRM7
tRNA

1

0

High-throughput

0.458

High

173830

MK13
Mitogen-activated protein kinase 13

1

4

Small-scale

0.445

High

556622

T22D1
TSC22 domain family protein 1

1

1

Small-scale

0.445

High

556626

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

122254

RN103
E3 ubiquitin-protein ligase RNF103

1

4

High-throughput

0.437

High

214074

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.437

High

345847

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

384211

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

551885

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

556588

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

556592

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

556594

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

556625

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

5

High-throughput

0.437

High

556629

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

556631

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

556632

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

3

High-throughput

0.437

High

556643

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

556651

RN185
E3 ubiquitin-protein ligase RNF185

1

3

High-throughput

0.437

High

556653

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.437

High

556655

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.437

High

556656

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.437

High

556664

TM208
Transmembrane protein 208

1

2

High-throughput

0.437

High

556671

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

High-throughput

0.437

High

556672

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

556673

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

556678

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

3

High-throughput

0.437

High

556683

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

556615

ERCC8
DNA excision repair protein ERCC-8

1

2

High-throughput

0.417

High

110617

H3BMW4
Transmembrane protein 208

1

2

High-throughput

0.407

High

401365

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

556603

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

556630

NEK10
Serine/threonine-protein kinase Nek10

1

2

High-throughput

0.407

High

183016

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

215800

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.279

Low

556634

CERS3
Ceramide synthase 3

1

0

High-throughput

0.279

Low

556637

PKHM2
Pleckstrin homology domain-containing family M member 2

1

0

High-throughput

0.279

Low

556638

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

556642

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

556665

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

556666

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

556676

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

556681

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

239490

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

243878

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

328727

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

525838

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.249

Low

556607

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

556620

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low

556649

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.249

Low

556652

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

556658

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.249

Low

556686

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

918

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

556635

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024