HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: FKBP8 (Q14318)
Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (EC 5.2.1.8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase)
Gene: FKBP8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	26618866, 31324722
Identification Methods	affinity chromatography technology, cross-linking study, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 412
+	Hs
		259921 CFTR_HUMAN (1-1480): 0: 1031: 100.00		FKBP6_HUMAN (81-380): 6.91e-56: 188: 23.73
+	Hs
		118685 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AIP_HUMAN (97-369): 4.45e-54: 184: 18.94
+	Hs
		528642 CFTR_HUMAN (1-1480): 0: 1031: 100.00		STIP1_HUMAN (218-357): 3.76e-20: 94.2: 20.00
+	At
		1176528 AB1C_ARATH (79-798): 1.27e-54: 212: 13.35		PAS1_ARATH (4-372): 1.64e-71: 238: 21.24
+	At
		1114624 AB2C_ARATH (54-787): 1.75e-55: 215: 12.63		FKB42_ARATH (53-391): 1.23e-57: 194: 23.43
+	At
		1320740 AB1C_ARATH (79-798): 1.27e-54: 212: 13.35		FKB42_ARATH (53-391): 1.23e-57: 194: 23.43
+	Hs
		972567 MRP9_HUMAN (129-648): 1.25e-56: 218: 14.61		FKBP4_HUMAN (72-404): 6.45e-24: 105: 18.18
+	Zm
		5411 A0A1D6DZ56_MAIZE (58-786): 6.1e-54: 210: 12.58		A0A1D6KJP4_MAIZE (117-200): 4.52e-19: 91.1: 34.09