Protein: THIL
Acetyl-CoA acetyltransferase, mitochondrial (EC 2.3.1.9) (Acetoacetyl-CoA thiolase) (T2)

Gene: THIL, ACAT1
Organism: Homo sapiens
Interactions: 173
UniProt ID: P24752

Gene Ontology (top 5):
GO:0001889 - liver development
GO:0003985 - acetyl-CoA C-acetyltransferase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

623985

THIC
Acetyl-CoA acetyltransferase, cytosolic

2

7

High-throughput

0.776

High

440347

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

3

3

Small-scale

0.674

High

226553

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.624

High

623927

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

3

High-throughput

0.618

High

345952

MYC
Myc proto-oncogene protein

3

4

Small-scale

0.585

High

262713

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

623939

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

624005

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

1

Small-scale

0.578

High

581435

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.576

High

623889

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

7

Small-scale

0.575

High

615646

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.537

High

204481

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

2

High-throughput

0.536

High

336365

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

623894

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

623917

KPCZ
Protein kinase C zeta type

1

3

High-throughput

0.536

High

623930

FAK2
Protein-tyrosine kinase 2-beta

1

2

High-throughput

0.536

High

623978

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.536

High

623940

RHG44
Rho GTPase-activating protein 44

2

1

High-throughput

0.521

High

623961

RHG24
Rho GTPase-activating protein 24

2

2

High-throughput

0.521

High

623962

SH2D3
SH2 domain-containing protein 3C

2

1

High-throughput

0.521

High

623963

DOCK8
Dedicator of cytokinesis protein 8

2

1

High-throughput

0.521

High

329369

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.515

High

443338

VIME
Vimentin

1

0

High-throughput

0.493

High

623959

DLP1
All trans-polyprenyl-diphosphate synthase PDSS2

1

0

High-throughput

0.493

High

201220

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

3

High-throughput

0.489

High

623937

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.489

High

623955

HEAT3
HEAT repeat-containing protein 3

1

1

High-throughput

0.489

High

134768

PEX7
Peroxisomal targeting signal 2 receptor

1

10

Small-scale

0.481

High

489904

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

1

Small-scale

0.481

High

119178

LEG9
Galectin-9

1

1

High-throughput

0.479

High

264840

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

269983

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

298165

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

354296

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

373696

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

428024

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

488126

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.479

High

499540

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.479

High

551972

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

623893

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.479

High

623896

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

623899

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

5

High-throughput

0.479

High

623901

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

623906

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

623907

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

623913

RHOB
Rho-related GTP-binding protein RhoB

1

5

High-throughput

0.479

High

623914

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

623915

TFAM
Transcription factor A, mitochondrial

1

1

High-throughput

0.479

High

623920

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

623922

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.479

High

623925

CUL3
Cullin-3

1

2

High-throughput

0.479

High

623936

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.479

High

623941

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

623946

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

623948

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

623950

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

2

High-throughput

0.479

High

623954

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

5

High-throughput

0.479

High

623957

TAXB1
Tax1-binding protein 1

1

4

High-throughput

0.479

High

623966

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

623967

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.479

High

623968

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

623969

FAKD4
FAST kinase domain-containing protein 4

1

5

High-throughput

0.479

High

623970

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

623971

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

1

High-throughput

0.479

High

623974

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

623977

EFGM
Elongation factor G, mitochondrial

1

1

High-throughput

0.479

High

623982

CQ080
Mitochondrial nucleoid-associated protein 1

1

1

High-throughput

0.479

High

623983

TMM70
Transmembrane protein 70, mitochondrial

1

1

High-throughput

0.479

High

623984

TR61B
tRNA

1

1

High-throughput

0.479

High

623986

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

623987

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

623989

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

623990

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

623992

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

623996

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.479

High

624000

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

3

High-throughput

0.479

High

624002

AKIP
Small ribosomal subunit protein mS38

1

1

High-throughput

0.479

High

624003

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

5

High-throughput

0.479

High

624007

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

624009

TNIK
TRAF2 and NCK-interacting protein kinase

1

4

High-throughput

0.479

High

624010

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

239497

EIF1B
Eukaryotic translation initiation factor 1b

1

2

High-throughput

0.470

High

59111

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

63289

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.458

High

243946

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

322197

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

327360

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

336841

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

486462

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

503459

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.458

High

530432

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

623898

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

623900

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

623904

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

623910

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

623916

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

623918

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

623919

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

623921

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

623929

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

623938

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

623972

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

623981

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

623988

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

623991

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

623993

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

623995

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

624001

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

624004

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

624006

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

624012

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

623976

LMTK3
Serine/threonine-protein kinase LMTK3

1

14

High-throughput

0.457

High

496328

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

623911

RHOA
Transforming protein RhoA

1

5

High-throughput

0.445

High

623934

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

5

Small-scale

0.445

High

623947

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

623973

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

624013

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

148409

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.437

High

214093

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.437

High

294380

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.437

High

384285

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.437

High

569203

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.437

High

617429

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.437

High

623890

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

623892

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

623897

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

623902

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.437

High

623903

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

623909

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.437

High

623912

WDR5
WD repeat-containing protein 5

1

6

High-throughput

0.437

High

623923

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.437

High

623924

CUL1
Cullin-1

1

2

High-throughput

0.437

High

623926

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.437

High

623931

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

623933

CUL7
Cullin-7

1

1

High-throughput

0.437

High

623935

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

623942

ARHGG
Rho guanine nucleotide exchange factor 16

1

1

High-throughput

0.437

High

623943

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.437

High

623944

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.437

High

623951

RHG36
Rho GTPase-activating protein 36

1

3

High-throughput

0.437

High

623952

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

623953

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.437

High

623958

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

623960

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.437

High

623965

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

623975

RCC1L
RCC1-like G exchanging factor-like protein

1

1

High-throughput

0.437

High

623994

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

623997

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.437

High

623998

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

1

High-throughput

0.437

High

623999

FBX6
F-box only protein 6

1

1

High-throughput

0.437

High

624008

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.437

High

624011

HDAC5
Histone deacetylase 5

1

4

High-throughput

0.437

High

927

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

371361

ANGI
Angiogenin

1

0

High-throughput

0.426

High

623908

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

High-throughput

0.407

High

623928

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.407

High

623895

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.279

Low

623956

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

0

High-throughput

0.279

Low

599287

AGT1
Alanine--glyoxylate aminotransferase

1

0

High-throughput

0.251

Low

172977

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.249

Low

224308

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.249

Low

351715

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

623891

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.249

Low

623905

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.249

Low

623932

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

623945

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

623949

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

623964

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

623979

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

0

High-throughput

0.249

Low

623980

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.249

Low

330855

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024