HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

Property	Details
Experiments	26618866, 10893422, 17110338, 18754678, 16203867, 28360110, 31324722, 12369822
Identification Methods	affinity chromatography technology, pull down, fluorescence polarization spectroscopy, anti bait coimmunoprecipitation, cross-linking study, enzyme linked immunosorbent assay
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane GO:0016324 - apical plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 337
+	Hs
		153866 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Mm
		641306 CFTR_MOUSE (1-1468): 0: 957: 78.29		NHRF1_MOUSE (2-337): 2.43e-68: 219: 48.88
+	Hs
		529050 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31
+	Hs
		529099 CFTR_HUMAN (1-1480): 0: 1031: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		529355 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF4_HUMAN (4-91): 1.55e-11: 67.2: 33.71
+	Hs
		529235 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		529578 CFTR_HUMAN (1-1480): 0: 1031: 100.00		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		529790 CFTR_HUMAN (1-1480): 0: 1031: 100.00		LIN7C_HUMAN (9-87): 8.5e-09: 56.6: 40.74
+	Hs
		179358 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153846 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Rn
		1144126 MRP2_RAT (773-1466): 1.07e-55: 215: 15.08		NHRF1_RAT (2-337): 3.63e-71: 226: 49.30
+	Hs
		153939 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		67899 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59
+	Hs
		179356 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		179363 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		179374 MRP4_HUMAN (5-647): 2.25e-59: 227: 15.67		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		1200079 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF4_HUMAN (4-91): 1.55e-11: 67.2: 33.71
+	Hs
		1132912 MRP2_HUMAN (798-1466): 4.31e-56: 217: 15.74		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45