HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26618866
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 4374
+	Hs
		529568 CFTR_HUMAN (1-1480): 0: 1031: 100.00		ITCH_HUMAN (3507-4372): 0: 672: 23.10
+	Hs
		125126 CFTR_HUMAN (1-1480): 0: 1031: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		529592 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NED4L_HUMAN (3542-4372): 0: 618: 27.53
+	Hs
		528744 CFTR_HUMAN (1-1480): 0: 1031: 100.00		NEDD4_HUMAN (3104-4372): 2.46e-179: 594: 21.46