HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: AT2A3 (Q93084)
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (SERCA3) (SR Ca(2+)-ATPase 3) (EC 7.2.2.10) (Calcium pump 3)
Gene: ATP2A3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	26618866, 17110338
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005789 - endoplasmic reticulum membrane GO:0016887 - ATP hydrolysis activity
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 999
+	Hs
		163736 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT2A1_HUMAN (1-999): 0: 946: 75.88
+	Hs
		528489 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT2A2_HUMAN (1-998): 0: 944: 76.75
+	Hs
		393007 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT1A1_HUMAN (3-999): 0: 807: 26.96
+	Hs
		528795 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT1A2_HUMAN (3-999): 0: 799: 26.96
+	Hs
		528564 CFTR_HUMAN (1-1480): 0: 1031: 100.00		AT2B4_HUMAN (5-997): 0: 767: 25.00
+	Hs
		163757 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		AT2A1_HUMAN (1-999): 0: 946: 75.88
+	Dm
		611085 Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95		ATC1_DROME (1-997): 0: 900: 67.60
+	Dm
		530302 Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95		ATNA_DROME (3-999): 0: 777: 27.05