HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: K1C23 (Q9C075)
Keratin, type I cytoskeletal 23 (Cytokeratin-23) (CK-23) (Keratin-23) (K23)
Gene: KRT23

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26618866
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1480 Hs			1 422
+	Hs
		359298 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C14_HUMAN (70-416): 3.2e-146: 425: 43.79
+	Hs
		529332 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C74_HUMAN (3-385): 4.12e-144: 422: 24.34
+	Hs
		529011 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C17_HUMAN (65-416): 3.98e-145: 421: 44.48
+	Hs
		529780 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT84_HUMAN (33-384): 1.8e-102: 318: 24.58
+	Hs
		529119 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT81_HUMAN (4-384): 7.28e-98: 303: 22.45
+	Hs
		213928 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT86_HUMAN (4-384): 2.94e-96: 298: 22.45
+	Hs
		528963 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT85_HUMAN (3-384): 3.43e-94: 293: 21.35
+	Hs
		318772 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C75_HUMAN (2-396): 3.89e-90: 284: 20.80
+	Hs
		528449 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C13_HUMAN (67-378): 1.69e-89: 280: 49.68
+	Hs
		529614 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C12_HUMAN (67-420): 1.36e-88: 279: 42.90
+	Hs
		444998 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C16_HUMAN (68-394): 6.15e-88: 276: 47.87
+	Hs
		444303 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1C19_HUMAN (64-390): 5.63e-86: 269: 44.51
+	Hs
		529503 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KRT35_HUMAN (1-386): 1.82e-84: 267: 40.05
+	Hs
		529130 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C72_HUMAN (20-385): 6.29e-82: 262: 23.58
+	Hs
		380440 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6B_HUMAN (36-401): 2.78e-80: 259: 20.60
+	Hs
		528450 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C5_HUMAN (36-392): 8.92e-80: 258: 23.06
+	Hs
		528760 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6C_HUMAN (36-397): 5.42e-80: 258: 21.10
+	Hs
		280490 CFTR_HUMAN (1-1480): 0: 1031: 100.00		KT33A_HUMAN (70-378): 1.87e-80: 255: 44.19
+	Hs
		359458 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K2C6A_HUMAN (36-401): 8.06e-79: 255: 20.87
+	Hs
		529151 CFTR_HUMAN (1-1480): 0: 1031: 100.00		K1H1_HUMAN (70-378): 2.93e-80: 255: 43.87