HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: MYO6 (Q9UM54)
Unconventional myosin-VI (Unconventional myosin-6)
Gene: MYO6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	20351096, 26618866, 29924966
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005765 - lysosomal membrane GO:0005829 - cytosol and 2 others more... GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 1294
+	Hs
		529767 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5C_HUMAN (772-1230): 2.22e-24: 113: 9.42
+	Hs
		522586 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7_HUMAN (766-1261): 3.15e-15: 83.6: 11.01
+	Hs
		64579 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH7B_HUMAN (761-1095): 2.05e-11: 71.2: 14.33
+	Hs
		528357 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH6_HUMAN (760-1113): 5.54e-10: 66.2: 18.89
+	Hs
		528675 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH9_HUMAN (842-1118): 6.25e-10: 66.2: 14.70
+	Hs
		528676 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH10_HUMAN (762-1135): 7.28e-10: 65.8: 15.54
+	Hs
		528682 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYH11_HUMAN (844-1177): 1.17e-09: 65.5: 18.55
+	Hs
		529903 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5B_HUMAN (1016-1294): 4.73e-09: 63.4: 12.41
+	Hs
		529959 CFTR_HUMAN (1-1480): 0: 1031: 100.00		MYO5A_HUMAN (595-1063): 4.98e-09: 63: 10.72