Protein: DERL2
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)

Gene: DERL2
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q9GZP9

Gene Ontology (top 5):
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0001967 - suckling behavior
GO:0005047 - signal recognition particle binding
GO:0005769 - early endosome
GO:0005770 - late endosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1313044

DERL1
Derlin-1

3

11

Small-scale

0.847

High

1287173

FAF2
FAS-associated factor 2

6

7

Small-scale

0.733

High

1198678

SYVN1
E3 ubiquitin-protein ligase synoviolin

6

8

Small-scale

0.721

High

1326111

AMFR
E3 ubiquitin-protein ligase AMFR

5

8

Small-scale

0.711

High

1326107

SE1L1
Protein sel-1 homolog 1

5

3

Small-scale

0.709

High

875295

TERA
Transitional endoplasmic reticulum ATPase

4

5

Small-scale

0.686

High

1326101

RTN4
Reticulon-4

3

7

High-throughput

0.662

High

1309553

SELS
Selenoprotein S

3

1

Small-scale

0.656

High

344239

A1AT
Alpha-1-antitrypsin

3

2

Small-scale

0.640

High

1034531

OS9
Protein OS-9

3

1

Small-scale

0.640

High

961816

REEP5
Receptor expression-enhancing protein 5

2

3

High-throughput

0.628

High

1087794

RTN1
Reticulon-1

2

7

High-throughput

0.628

High

1311383

ESYT1
Extended synaptotagmin-1

2

3

High-throughput

0.611

High

958849

EM55
55 kDa erythrocyte membrane protein

2

0

High-throughput

0.580

High

1260985

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

803734

BAG6
Large proline-rich protein BAG6

2

0

Small-scale

0.559

High

796438

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

3

High-throughput

0.553

High

134407

ACKR2
Atypical chemokine receptor 2

1

3

High-throughput

0.536

High

172215

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.536

High

234990

SNX3
Sorting nexin-3

1

2

High-throughput

0.536

High

277753

PRAF3
PRA1 family protein 3

1

2

High-throughput

0.536

High

307113

RTN3
Reticulon-3

1

7

High-throughput

0.536

High

438506

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.536

High

529696

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

560241

NCPR
NADPH--cytochrome P450 reductase

1

2

High-throughput

0.536

High

573892

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

3

High-throughput

0.536

High

626589

FPR2
N-formyl peptide receptor 2

1

6

High-throughput

0.536

High

686377

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

1

High-throughput

0.536

High

809966

STT3A
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A

1

1

High-throughput

0.536

High

897947

RAP1B
Ras-related protein Rap-1b

1

1

High-throughput

0.536

High

1040512

SNX1
Sorting nexin-1

1

2

High-throughput

0.536

High

1041463

CUL2
Cullin-2

1

1

High-throughput

0.536

High

1042491

CUL3
Cullin-3

1

1

High-throughput

0.536

High

1062654

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.536

High

1202373

RETR3
Reticulophagy regulator 3

1

2

High-throughput

0.536

High

1236984

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.536

High

1267601

UBXN4
UBX domain-containing protein 4

1

5

High-throughput

0.536

High

1283270

CCD47
PAT complex subunit CCDC47

1

1

High-throughput

0.536

High

1288815

ERLEC
Endoplasmic reticulum lectin 1

1

3

High-throughput

0.536

High

1293428

CREL1
Protein disulfide isomerase CRELD1

1

1

High-throughput

0.536

High

1326110

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.536

High

889394

KR107
Keratin-associated protein 10-7

1

3

High-throughput

0.523

High

889674

KR108
Keratin-associated protein 10-8

1

2

High-throughput

0.523

High

118991

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

391164

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

592480

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.513

High

896677

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

1038694

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.513

High

1223260

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.513

High

1233035

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1282825

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.513

High

1308601

CND3
Condensin complex subunit 3

1

0

High-throughput

0.513

High

1326096

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1326104

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.513

High

1326105

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.513

High

1326109

NAT8B
Putative N-acetyltransferase 8B

1

0

High-throughput

0.513

High

1326113

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

0

High-throughput

0.513

High

156924

FFAR1
Free fatty acid receptor 1

1

9

High-throughput

0.489

High

328389

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.489

High

723399

APJ
Apelin receptor

1

3

High-throughput

0.489

High

770244

GPV
Platelet glycoprotein V

1

1

High-throughput

0.489

High

782470

P2RY2
P2Y purinoceptor 2

1

6

High-throughput

0.489

High

814591

P2RY1
P2Y purinoceptor 1

1

6

High-throughput

0.489

High

849705

CCR6
C-C chemokine receptor type 6

1

2

High-throughput

0.489

High

1132967

CSCL2
CSC1-like protein 2

1

1

High-throughput

0.489

High

1202732

P2RY8
P2Y purinoceptor 8

1

6

High-throughput

0.489

High

1268647

LPAR1
Lysophosphatidic acid receptor 1

1

4

High-throughput

0.489

High

1292926

GWL
Serine/threonine-protein kinase greatwall

1

1

High-throughput

0.489

High

1326094

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.489

High

1326098

LPAR2
Lysophosphatidic acid receptor 2

1

3

High-throughput

0.489

High

1326099

GPR35
G-protein coupled receptor 35

1

5

High-throughput

0.489

High

1326103

GP173
Probable G-protein coupled receptor 173

1

1

High-throughput

0.489

High

48028

TM129
E3 ubiquitin-protein ligase TM129

1

1

Small-scale

0.479

High

48493

ESYT2
Extended synaptotagmin-2

1

3

High-throughput

0.479

High

168026

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

377663

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

894976

SRP54
Signal recognition particle subunit SRP54

1

3

Small-scale

0.479

High

900872

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

901526

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

3

Small-scale

0.479

High

1062924

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

2

Small-scale

0.479

High

1074305

SHH
Sonic hedgehog protein

1

1

Small-scale

0.479

High

1307259

RNF5
E3 ubiquitin-protein ligase RNF5

1

4

Small-scale

0.479

High

1326114

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

5

Small-scale

0.479

High

409224

K2C8
Keratin, type II cytoskeletal 8

1

0

Small-scale

0.458

High

1268006

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1286049

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

Small-scale

0.458

High

360386

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.439

High

888987

KR103
Keratin-associated protein 10-3

1

2

High-throughput

0.439

High

363651

TTHY
Transthyretin

1

2

Small-scale

0.437

High

1156705

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1222097

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.437

High

1326106

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

1

Small-scale

0.437

High

1326115

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

1

Small-scale

0.437

High

99678

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

1229660

RBFA
Putative ribosome-binding factor A, mitochondrial

2

0

High-throughput

0.316

High

1326095

FXYD6
FXYD domain-containing ion transport regulator 6

2

0

High-throughput

0.316

High

1326102

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.316

High

206523

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

271946

FCN3
Ficolin-3

1

0

High-throughput

0.279

Low

326206

TSN15
Tetraspanin-15

1

0

High-throughput

0.279

Low

440720

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.279

Low

579602

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.279

Low

658290

5HT2C
5-hydroxytryptamine receptor 2C

1

0

High-throughput

0.279

Low

674972

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.279

Low

702407

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

849582

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.279

Low

965833

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.279

Low

1168199

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1218977

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1254654

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1299235

OPALI
Opalin

1

0

High-throughput

0.279

Low

1312159

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.279

Low

1326100

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.279

Low

1326112

FZD1
Frizzled-1

1

0

High-throughput

0.279

Low

205950

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

1326097

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1326108

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024