HitPredict

Interactor 1: K2C5 (P13647)
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)
Gene: KRT5

Interactor 2: K1H2 (Q14532)
Keratin, type I cuticular Ha2 (Hair keratin, type I Ha2) (Keratin-32) (K32)
Gene: KRT32

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	36949045
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0008544 - epidermis development GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 590 Hs			1 448
+	Hs
		359297 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C14_HUMAN (94-407): 1.1e-141: 415: 59.87
+	Hs
		517735 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C13_HUMAN (85-419): 3.5e-139: 408: 55.06
+	Hs
		444302 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C19_HUMAN (87-406): 6.81e-139: 405: 56.25
+	Hs
		444997 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C16_HUMAN (92-419): 7.7e-138: 405: 55.79
+	Hs
		517737 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C15_HUMAN (95-407): 5.04e-137: 402: 59.24
+	Hs
		49556 K22E_HUMAN (140-484): 3.01e-174: 509: 71.88		A1A4E9_HUMAN (85-419): 3.08e-139: 408: 54.76
+	Hs
		280517 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		KRT34_HUMAN (44-429): 1.55e-112: 338: 67.88
+	Hs
		517762 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C39_HUMAN (2-444): 1.28e-109: 333: 55.71
+	Hs
		280536 K22E_HUMAN (140-484): 3.01e-174: 509: 71.88		KRT34_HUMAN (44-429): 1.55e-112: 338: 67.88
+	Hs
		517740 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C20_HUMAN (92-406): 3.48e-97: 300: 51.11
+	Hs
		517752 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1H2_HUMAN (1-448): 1.48e-96: 299: 100.00
+	Hs
		517761 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1C40_HUMAN (1-426): 1.07e-84: 268: 57.48
+	Hs
		517751 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		KT33B_HUMAN (46-438): 5.49e-85: 267: 67.09
+	Hs
		318771 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K2C75_HUMAN (4-421): 1.62e-81: 263: 22.54
+	Hs
		517773 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		KRT35_HUMAN (1-444): 1.58e-80: 258: 64.05
+	Hs
		280772 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		KRT36_HUMAN (2-414): 6.42e-77: 248: 67.07
+	Hs
		280946 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		KRT38_HUMAN (11-448): 2.28e-74: 241: 54.36
+	Hs
		280777 K22E_HUMAN (140-484): 3.01e-174: 509: 71.88		KRT36_HUMAN (2-414): 6.42e-77: 248: 67.07
+	Hs
		280847 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		KRT37_HUMAN (1-440): 1.52e-71: 234: 53.35
+	Hs
		517754 K2C3_HUMAN (140-484): 3.95e-178: 519: 78.10		K1H1_HUMAN (46-429): 2.32e-71: 233: 70.05