HitPredict

Interactor 1: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Interactor 2: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	24981860, 34079125, 37071682
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005783 - endoplasmic reticulum GO:0005788 - endoplasmic reticulum lumen GO:0006457 - protein folding GO:0034976 - response to endoplasmic reticulum stress and 1 others more... GO:0042470 - melanosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 803
+	Rn
		751963 PDIA4_RAT (25-645): 0: 549: 87.12		ENPL_RAT (1-803): 0: 1055: 95.03
+	Hs
		538309 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		538242 PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Hs
		538119 PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35		ENPL_HUMAN (1-803): 0: 1073: 100.00
+	Dm
		870455 PDI_DROME (53-504): 1.95e-49: 181: 20.13		Q9VAY2_DROME (16-751): 0: 919: 62.28
+	Sc
		543146 PDI_YEAST (523-645): 2.02e-24: 109: 24.39		HSC82_YEAST (72-783): 0: 869: 47.57