HitPredict

Interactor 1: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Interactor 2: PRDX3 (P30048)
Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3)
Gene: PRDX3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	1-cysPrx_C~Thioredoxin, AhpC-TSA~Thioredoxin
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 645 Hs			1 256
+	Hs
		531815 PDIA4_HUMAN (1-645): 0: 571: 100.00		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Rn
		751965 PDIA4_RAT (25-645): 0: 549: 87.12		PRDX4_RAT (30-255): 3.32e-105: 307: 58.41
+	Hs
		1026716 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Hs
		423216 PDIA1_HUMAN (4-165): 4.25e-32: 132: 27.11		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Hs
		1026686 PDIA6_HUMAN (57-283): 2.92e-31: 128: 28.51		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Hs
		671804 PDIA3_HUMAN (7-188): 4.76e-28: 120: 28.35		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Hs
		1026726 TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48		PRDX4_HUMAN (35-255): 3.38e-103: 302: 58.82
+	Hs
		685729 TXND5_HUMAN (547-631): 1.03e-21: 100: 34.48		PRDX2_HUMAN (58-255): 2.07e-104: 302: 63.13
+	Dm
		870432 PDI_DROME (53-504): 1.95e-49: 181: 20.13		Q7JX87_DROME (64-256): 3.48e-70: 216: 26.60