HitPredict

Interactor 1: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Interactor 2: PDIA3 (P30101)
Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)
Gene: PDIA3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.893

The method score is based on:

Property Details
Experiments 34079125, 37071682, 24981860, 17170699
Identification Methods proximity labelling technology, cross-linking study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, disulfide bond

The annotation score is based on:

Property Details
Interacting Pfam domains Thioredoxin~Thioredoxin, Thioredoxin~Thioredoxin_6, Thioredoxin_6~Thioredoxin_6
Common GO terms GO:0003723 - RNA binding
GO:0003756 - protein disulfide isomerase activity
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
and 5 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 645
Hs

1 505
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+ Rn
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+ Hs
+ Dm
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+ Ce
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+ Mm
+ Rn
+ Mm
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+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024