HitPredict

Interactor 1: PDIA4 (P13667)
Protein disulfide-isomerase A4 (EC 5.3.4.1) (Endoplasmic reticulum resident protein 70) (ER protein 70) (ERp70) (Endoplasmic reticulum resident protein 72) (ER protein 72) (ERp-72) (ERp72)
Gene: PDIA4

Interactor 2: TYRO3 (Q06418)
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
Gene: TYRO3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0009986 - cell surface
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 645 Hs			1 890
+	Hs
		531732 PDIA4_HUMAN (1-645): 0: 571: 100.00		EPHB2_HUMAN (72-826): 1.04e-178: 546: 20.21
+	Hs
		531731 PDIA4_HUMAN (1-645): 0: 571: 100.00		EPHA8_HUMAN (116-808): 3.82e-166: 511: 20.03
+	Hs
		531857 PDIA4_HUMAN (1-645): 0: 571: 100.00		EPHAA_HUMAN (203-842): 1.14e-129: 416: 23.35
+	Rn
		102493 G3V6T7_RAT (25-645): 0: 550: 87.28		INSR_RAT (232-788): 7.04e-127: 416: 27.65
+	Hs
		441417 PDIA4_HUMAN (1-645): 0: 571: 100.00		MET_HUMAN (495-790): 3.89e-65: 240: 41.67
+	Hs
		435520 PDIA4_HUMAN (1-645): 0: 571: 100.00		IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53
+	Hs
		411285 PDIA4_HUMAN (1-645): 0: 571: 100.00		INSR_HUMAN (292-790): 2.17e-60: 226: 31.15
+	Hs
		531803 PDIA4_HUMAN (1-645): 0: 571: 100.00		RON_HUMAN (500-793): 2.58e-59: 223: 41.95
+	Hs
		445818 PDIA4_HUMAN (1-645): 0: 571: 100.00		ROS1_HUMAN (279-787): 2.73e-55: 211: 30.76
+	Hs
		434126 PDIA4_HUMAN (1-645): 0: 571: 100.00		RET_HUMAN (514-790): 1.89e-55: 210: 39.93
+	Hs
		531743 PDIA4_HUMAN (1-645): 0: 571: 100.00		RYK_HUMAN (503-782): 8.78e-55: 202: 37.50
+	Hs
		507820 PDIA4_HUMAN (1-645): 0: 571: 100.00		FGFR1_HUMAN (6-230): 2.63e-19: 95.6: 18.22
+	Hs
		531740 PDIA4_HUMAN (1-645): 0: 571: 100.00		UFO_HUMAN (6-344): 1.91e-14: 79.8: 14.56
+	Hs
		531813 PDIA4_HUMAN (1-645): 0: 571: 100.00		MERTK_HUMAN (6-315): 1.52e-12: 73.6: 15.71
+	Rn
		544870 PDIA6_RAT (392-645): 4.37e-51: 185: 19.85		INSR_RAT (232-788): 7.04e-127: 416: 27.65
+	Hs
		435692 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53
+	Hs
		411430 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		INSR_HUMAN (292-790): 2.17e-60: 226: 31.15
+	Hs
		445858 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		ROS1_HUMAN (279-787): 2.73e-55: 211: 30.76
+	Hs
		537757 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		INSRR_HUMAN (513-780): 3.2e-53: 204: 39.56
+	Hs
		674477 DJC10_HUMAN (41-295): 2.22e-45: 174: 22.47		UFO_HUMAN (6-344): 1.91e-14: 79.8: 14.56