HitPredict

Interactor 1: CH60 (P10809)
60 kDa heat shock protein, mitochondrial (EC 5.6.1.7) (60 kDa chaperonin) (Chaperonin 60) (CPN60) (Heat shock protein 60) (HSP-60) (Hsp60) (Heat shock protein family D member 1) (HuCHA60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein)
Gene: HSPD1

Interactor 2: CH10 (P61604)
10 kDa heat shock protein, mitochondrial (Hsp10) (10 kDa chaperonin) (Chaperonin 10) (CPN10) (Early-pregnancy factor) (EPF) (Heat shock protein family E member 1)
Gene: HSPE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.934

The method score is based on:

Property	Details
Experiments	29568061, 10205158, 12387818, 39358380, 39422127, 14717702
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid, cross-linking study, pull down
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	Cpn10~Cpn60_TCP1
Common GO terms	GO:0003723 - RNA binding GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0005759 - mitochondrial matrix GO:0006457 - protein folding and 5 others more... GO:0006986 - response to unfolded protein GO:0016020 - membrane GO:0051082 - unfolded protein binding GO:0051087 - protein-folding chaperone binding GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	573
Hs

1	102

Service provided by Combinatics, Japan

Last updated: 11Aug2025