HitPredict

Interactor 1: CCL4 (P14097)
C-C motif chemokine 4 (Immune activation protein 2) (ACT-2) (ACT2) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4)
Gene: CCL4

Interactor 2: CCR3 (P51678)
Probable C-C chemokine receptor type 3 (C-C CKR-3) (CC-CKR-3) (CCR-3) (CCR3) (CKR3) (Macrophage inflammatory protein 1-alpha receptor-like 2) (MIP-1 alpha RL2) (CD antigen CD193)
Gene: CCR3

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9139699
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0005615 - extracellular space GO:0006954 - inflammatory response GO:0048245 - eosinophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 92 Mm			1 359
+	Mm
		500591 CCL3_MOUSE (1-92): 1.06e-36: 120: 59.78		CCR3_MOUSE (1-359): 1.27e-91: 280: 100.00
+	Hs
		561728 CL3L1_HUMAN (1-92): 8e-38: 123: 59.78		CCR1_HUMAN (20-359): 9.78e-87: 267: 65.29
+	Hs
		526560 CCL4_HUMAN (1-92): 1.69e-37: 122: 76.09		CCR1_HUMAN (20-359): 9.78e-87: 267: 65.29
+	Hs
		686667 CCL14_HUMAN (1-92): 1.14e-35: 118: 45.16		CCR1_HUMAN (20-359): 9.78e-87: 267: 65.29
+	Mm
		500590 CCL3_MOUSE (1-92): 1.06e-36: 120: 59.78		CCR1_MOUSE (16-359): 3.84e-79: 247: 62.50
+	Hs
		783833 CCL13_HUMAN (1-91): 2.11e-37: 122: 39.56		CCR2_HUMAN (17-332): 1.05e-75: 239: 53.63
+	Hs
		561732 CL3L1_HUMAN (1-92): 8e-38: 123: 59.78		CCR3_HUMAN (13-359): 8.75e-72: 229: 70.03
+	Hs
		561733 CL3L1_HUMAN (1-92): 8e-38: 123: 59.78		CCR5_HUMAN (19-358): 6.47e-72: 229: 55.26
+	Hs
		526564 CCL4_HUMAN (1-92): 1.69e-37: 122: 76.09		CCR3_HUMAN (13-359): 8.75e-72: 229: 70.03
+	Hs
		526565 CCL4_HUMAN (1-92): 1.69e-37: 122: 76.09		CCR5_HUMAN (19-358): 6.47e-72: 229: 55.26
+	Hs
		849619 CCL13_HUMAN (1-91): 2.11e-37: 122: 39.56		CCR3_HUMAN (13-359): 8.75e-72: 229: 70.03
+	Hs
		849654 CCL13_HUMAN (1-91): 2.11e-37: 122: 39.56		CCR5_HUMAN (19-358): 6.47e-72: 229: 55.26
+	Hs
		849616 CCL14_HUMAN (1-92): 1.14e-35: 118: 45.16		CCR3_HUMAN (13-359): 8.75e-72: 229: 70.03
+	Hs
		1305163 CCL13_HUMAN (1-91): 2.11e-37: 122: 39.56		ACKR4_HUMAN (4-347): 2.67e-69: 222: 32.00
+	Hs
		134356 CCL4_HUMAN (1-92): 1.69e-37: 122: 76.09		ACKR2_HUMAN (28-320): 1.01e-54: 186: 38.44
+	Hs
		134400 CCL13_HUMAN (1-91): 2.11e-37: 122: 39.56		ACKR2_HUMAN (28-320): 1.01e-54: 186: 38.44
+	Hs
		134380 CCL14_HUMAN (1-92): 1.14e-35: 118: 45.16		ACKR2_HUMAN (28-320): 1.01e-54: 186: 38.44
+	Mm
		139696 CCL2_MOUSE (1-92): 1.22e-34: 117: 38.71		ACKR2_MOUSE (8-320): 2.02e-45: 161: 34.27
+	Hs
		830629 CCL13_HUMAN (1-91): 2.11e-37: 122: 39.56		CXCR3_HUMAN (3-322): 3.48e-42: 152: 32.02
+	Hs
		526561 CCL4_HUMAN (1-92): 1.69e-37: 122: 76.09		CXCR5_HUMAN (16-316): 1.72e-41: 150: 31.07