Protein: MK07
Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)

Gene: MK07, MAPK7
Organism: Homo sapiens
Interactions: 143
UniProt ID: Q13164

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004674 - protein serine/threonine kinase activity
GO:0004707 - MAP kinase activity
GO:0004857 - enzyme inhibitor activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1097089

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

7

20

Small-scale

0.974

High

1097129

MK07
Mitogen-activated protein kinase 7

3

19

Small-scale

0.853

High

1097177

M3K2
Mitogen-activated protein kinase kinase kinase 2

2

20

Small-scale

0.789

High

600412

ZKSC1
Zinc finger protein with KRAB and SCAN domains 1

2

1

High-throughput

0.783

High

468327

HS90B
Heat shock protein HSP 90-beta

2

20

Small-scale

0.754

High

1097140

CDC37
Hsp90 co-chaperone Cdc37

2

9

Small-scale

0.754

High

1051219

KPCZ
Protein kinase C zeta type

1

20

Small-scale

0.740

High

531057

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

6

High-throughput

0.737

High

703568

MK01
Mitogen-activated protein kinase 1

2

18

High-throughput

0.737

High

727782

DNJA1
DnaJ homolog subfamily A member 1

2

9

High-throughput

0.737

High

993156

ACTG
Actin, cytoplasmic 2

2

8

High-throughput

0.737

High

1097144

ACTBL
Beta-actin-like protein 2

2

8

High-throughput

0.737

High

1097170

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

2

20

High-throughput

0.737

High

400758

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.724

High

122946

SGK1
Serine/threonine-protein kinase Sgk1

1

20

Small-scale

0.709

High

578471

BRAF
Serine/threonine-protein kinase B-raf

1

20

High-throughput

0.708

High

478023

SNRPA
U1 small nuclear ribonucleoprotein A

1

11

High-throughput

0.691

High

1093218

FLII
Protein flightless-1 homolog

1

5

High-throughput

0.691

High

963284

PFD3
Prefoldin subunit 3

4

1

High-throughput

0.691

High

1097167

PFD4
Prefoldin subunit 4

4

1

High-throughput

0.691

High

182120

PFD6
Prefoldin subunit 6

4

0

High-throughput

0.661

High

261797

PFD1
Prefoldin subunit 1

4

0

High-throughput

0.661

High

1097157

PFD5
Prefoldin subunit 5

4

0

High-throughput

0.661

High

1097172

PFD2
Prefoldin subunit 2

4

0

High-throughput

0.661

High

144175

UBE2C
Ubiquitin-conjugating enzyme E2 C

3

3

High-throughput

0.654

High

714079

PML
Protein PML

2

12

Small-scale

0.646

High

1055018

MEF2C
Myocyte-specific enhancer factor 2C

2

16

Small-scale

0.633

High

411853

NTRK1
High affinity nerve growth factor receptor

1

19

High-throughput

0.618

High

461431

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

573456

ENPL
Endoplasmin

1

20

Small-scale

0.618

High

603259

KPCA
Protein kinase C alpha type

1

14

High-throughput

0.618

High

952795

ACTB
Actin, cytoplasmic 1

1

8

Small-scale

0.618

High

1097130

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.618

High

1097148

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1097163

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

20

Small-scale

0.618

High

1097164

PKHA4
Pleckstrin homology domain-containing family A member 4

1

11

High-throughput

0.618

High

1034677

MEF2A
Myocyte-specific enhancer factor 2A

2

16

Small-scale

0.614

High

408846

G3P
Glyceraldehyde-3-phosphate dehydrogenase

2

5

Small-scale

0.611

High

1097138

CCDC6
Coiled-coil domain-containing protein 6

2

6

High-throughput

0.606

High

422035

A4
Amyloid-beta precursor protein

2

2

High-throughput

0.602

High

971473

1433E
14-3-3 protein epsilon

2

8

Small-scale

0.586

High

729798

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.586

High

1097135

MEF2D
Myocyte-specific enhancer factor 2D

1

16

Small-scale

0.586

High

346995

BAG2
BAG family molecular chaperone regulator 2

2

0

High-throughput

0.585

High

605659

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

15

High-throughput

0.575

High

240086

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

9

High-throughput

0.571

High

255621

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

2

1

High-throughput

0.571

High

256849

H2B1K
Histone H2B type 1-K

2

11

High-throughput

0.571

High

339487

ACSL3
Fatty acid CoA ligase Acsl3

2

2

High-throughput

0.571

High

408041

TBB4A
Tubulin beta-4A chain

2

8

High-throughput

0.571

High

415536

HSPB1
Heat shock protein beta-1

2

5

High-throughput

0.571

High

420513

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

2

7

High-throughput

0.571

High

424879

ADT2
ADP/ATP translocase 2

2

11

High-throughput

0.571

High

537088

HSP7C
Heat shock cognate 71 kDa protein

2

8

High-throughput

0.571

High

549583

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

9

High-throughput

0.571

High

552219

ADT3
ADP/ATP translocase 3

2

11

High-throughput

0.571

High

598072

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

2

6

High-throughput

0.571

High

697514

PYR1
Multifunctional protein CAD

2

9

High-throughput

0.571

High

722703

AL1B1
Aldehyde dehydrogenase X, mitochondrial

2

3

High-throughput

0.571

High

943348

H2BFS
Histone H2B type F-S

2

11

High-throughput

0.571

High

946767

H2B1D
Histone H2B type 1-D

2

11

High-throughput

0.571

High

954462

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

9

High-throughput

0.571

High

996679

TBA1B
Tubulin alpha-1B chain

2

8

High-throughput

0.571

High

997310

TBB4B
Tubulin beta-4B chain

2

8

High-throughput

0.571

High

1032298

OTUD4
OTU domain-containing protein 4

2

1

High-throughput

0.571

High

1097131

TBB2A
Tubulin beta-2A chain

2

8

High-throughput

0.571

High

1097132

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

9

High-throughput

0.571

High

1097136

IMB1
Importin subunit beta-1

2

4

High-throughput

0.571

High

1097142

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

2

1

High-throughput

0.571

High

1097146

H2B2F
Histone H2B type 2-F

2

11

High-throughput

0.571

High

1097152

H2B1H
Histone H2B type 1-H

2

11

High-throughput

0.571

High

1097155

IPO9
Importin-9

2

5

High-throughput

0.571

High

1097158

H2B1N
Histone H2B type 1-N

2

11

High-throughput

0.571

High

1097159

H2B1M
Histone H2B type 1-M

2

11

High-throughput

0.571

High

1097160

H2B1L
Histone H2B type 1-L

2

11

High-throughput

0.571

High

1097169

ATD3A
ATPase family AAA domain-containing protein 3A

2

8

High-throughput

0.571

High

1097171

LIMA1
LIM domain and actin-binding protein 1

2

4

High-throughput

0.571

High

1097173

MYO5B
Unconventional myosin-Vb

2

4

High-throughput

0.571

High

1097174

COR1C
Coronin-1C

2

2

High-throughput

0.571

High

1097175

RUVB2
RuvB-like 2

2

7

High-throughput

0.571

High

1097176

RUVB1
RuvB-like 1

2

7

High-throughput

0.571

High

1097181

NS1BP
Influenza virus NS1A-binding protein

2

2

High-throughput

0.571

High

577435

ETS1
Protein C-ets-1

1

19

Small-scale

0.561

High

603960

CXA1
Gap junction alpha-1 protein

1

3

Small-scale

0.561

High

1097137

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

20

Small-scale

0.561

High

1097139

NF2L2
Nuclear factor erythroid 2-related factor 2

1

20

Small-scale

0.561

High

467473

4F2
Amino acid transporter heavy chain SLC3A2

2

0

High-throughput

0.547

High

1031783

LAT1
Large neutral amino acids transporter small subunit 1

2

0

High-throughput

0.547

High

1042578

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

2

0

High-throughput

0.547

High

1097156

MMS19
MMS19 nucleotide excision repair protein homolog

2

0

High-throughput

0.547

High

1097161

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

2

0

High-throughput

0.547

High

282937

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

15

High-throughput

0.541

High

899871

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

1097134

GOGB1
Golgin subfamily B member 1

1

10

High-throughput

0.541

High

1097165

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.541

High

1097166

SH22A
SH2 domain-containing protein 2A

1

9

High-throughput

0.541

High

1097168

FGF21
Fibroblast growth factor 21

1

1

High-throughput

0.541

High

479133

ENOG
Gamma-enolase

1

2

High-throughput

0.536

High

568635

GYS1
Glycogen [starch] synthase, muscle

1

2

High-throughput

0.536

High

577738

PLAK
Junction plakoglobin

1

6

High-throughput

0.536

High

628771

TBP
TATA-box-binding protein

1

1

High-throughput

0.536

High

1036716

DSG1
Desmoglein-1

1

6

High-throughput

0.536

High

1097149

TRM1L
tRNA

1

3

High-throughput

0.536

High

1097150

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.536

High

1097179

MYO5A
Unconventional myosin-Va

1

5

High-throughput

0.536

High

552000

ADT1
ADP/ATP translocase 1

2

9

High-throughput

0.521

High

1024341

S25A3
Solute carrier family 25 member 3

2

13

High-throughput

0.521

High

1097143

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

2

1

High-throughput

0.521

High

1097151

GSLG1
Golgi apparatus protein 1

2

2

High-throughput

0.521

High

1097154

MACIR
Macrophage immunometabolism regulator

1

0

High-throughput

0.518

High

1097147

Q5TZN3
Ubiquitin-conjugating enzyme E2 C

1

3

High-throughput

0.515

High

913247

TF2AA
Transcription initiation factor IIA subunit 1

1

0

High-throughput

0.513

High

370650

FOS
Protein c-Fos

1

17

Small-scale

0.501

High

698621

CALX
Calnexin

1

1

High-throughput

0.489

High

1064421

DSC1
Desmocollin-1

1

5

High-throughput

0.489

High

1097145

NOM1
Nucleolar MIF4G domain-containing protein 1

1

2

High-throughput

0.489

High

224701

ACTN4
Alpha-actinin-4

1

9

High-throughput

0.481

High

1097178

GPSM3
G-protein-signaling modulator 3

1

1

High-throughput

0.481

High

95883

E7EPN9
Proline rich coiled-coil 2C

1

9

High-throughput

0.479

High

172764

XPO1
Exportin-1

1

6

High-throughput

0.479

High

347673

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.479

High

413747

P53
Cellular tumor antigen p53

1

7

Small-scale

0.479

High

457407

TBB5
Tubulin beta chain

1

8

Small-scale

0.479

High

460916

LDHC
L-lactate dehydrogenase C chain

1

4

Small-scale

0.479

High

535006

BIP
Endoplasmic reticulum chaperone BiP

1

12

Small-scale

0.479

High

573087

KPYM
Pyruvate kinase PKM

1

5

Small-scale

0.479

High

606710

CEBPB
CCAAT/enhancer-binding protein beta

1

17

High-throughput

0.479

High

680342

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

11

Small-scale

0.479

High

761660

HSP74
Heat shock 70 kDa protein 4

1

12

Small-scale

0.479

High

966266

1433G
14-3-3 protein gamma

1

20

Small-scale

0.479

High

990176

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.479

High

1049251

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

1062362

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

7

Small-scale

0.479

High

1097141

FSCN1
Fascin

1

1

Small-scale

0.479

High

1097162

PRAX
Periaxin

1

12

High-throughput

0.479

High

1097180

PRC2C
Protein PRRC2C

1

10

High-throughput

0.479

High

980738

H2B1C
Histone H2B type 1-C/E/F/G/I

1

11

High-throughput

0.445

High

1097133

GANAB
Neutral alpha-glucosidase AB

1

1

Small-scale

0.437

High

641946

CD9
CD9 antigen

2

0

High-throughput

0.298

High

944246

TMM33
Transmembrane protein 33

2

0

High-throughput

0.298

High

1085975

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.298

High

1097153

ZB10P
Putative protein ZBED10P

1

0

High-throughput

0.282

High


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Last updated: 11Aug2025