HitPredict

Interactor 1: GFAP (P14136)
Glial fibrillary acidic protein (GFAP)
Gene: GFAP

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0010467 - gene expression
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 432 Hs			1 594
+	Hs
		411976 GFAP_HUMAN (1-432): 1.24e-150: 436: 100.00		FYN_HUMAN (441-591): 5.64e-47: 174: 20.38
+	Hs
		433235 GFAP_HUMAN (1-432): 1.24e-150: 436: 100.00		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		443403 VIME_HUMAN (16-431): 4.89e-138: 405: 57.28		BLK_HUMAN (449-593): 3.44e-45: 169: 22.82
+	Hs
		433246 DESM_HUMAN (50-432): 5.94e-119: 356: 61.62		YES_HUMAN (441-592): 9.17e-47: 174: 20.89
+	Hs
		535366 GFAP_HUMAN (1-432): 1.24e-150: 436: 100.00		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		443451 VIME_HUMAN (16-431): 4.89e-138: 405: 57.28		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		409046 K2C8_HUMAN (42-425): 3.04e-135: 398: 32.53		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		280771 KRT36_HUMAN (1-428): 9.2e-74: 240: 26.20		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		442865 KRT35_HUMAN (2-377): 4.53e-74: 240: 28.50		HCK_HUMAN (406-593): 7.97e-46: 171: 18.78
+	Hs
		924679 K2C73_HUMAN (9-380): 1.62e-93: 293: 31.03		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924576 KRT81_HUMAN (9-381): 3.28e-92: 289: 32.18		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924469 KRT83_HUMAN (9-384): 3.31e-92: 288: 32.72		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		213936 KRT86_HUMAN (9-384): 1.36e-90: 284: 32.45		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924470 KRT85_HUMAN (6-384): 7.66e-89: 280: 32.20		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924895 KRT82_HUMAN (1-394): 3.99e-87: 276: 31.23		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		531551 K2C5_HUMAN (34-380): 1.51e-73: 243: 32.39		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		280786 KRT36_HUMAN (1-428): 9.2e-74: 240: 26.20		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924575 K1H2_HUMAN (7-384): 4.57e-74: 240: 28.61		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924741 KRT35_HUMAN (2-377): 4.53e-74: 240: 28.50		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		359480 K2C6A_HUMAN (34-396): 7.63e-72: 237: 30.71		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89