HitPredict - High confidence protein-protein interactions

Interactor 1: PERF (P14222)
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
Gene: PRF1

Interactor 2: PERF (P14222)
Perforin-1 (P1) (Cytolysin) (Lymphocyte pore-forming protein) (PFP)
Gene: PRF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.821

Property	Details
Experiments	21685908, 21037563
Identification Methods	pull down, comigration in non denaturing gel electrophoresis, 3D electron microscopy, transmission electron microscopy, comigration in gel electrophoresis
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C2~C2, MACPF~MACPF
Common GO terms	GO:0001771 - immunological synapse formation GO:0001772 - immunological synapse GO:0001913 - T cell mediated cytotoxicity GO:0002357 - defense response to tumor cell GO:0002418 - immune response to tumor cell and 20 others more... GO:0005509 - calcium ion binding GO:0005576 - extracellular region GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0006968 - cellular defense response GO:0009306 - protein secretion GO:0016020 - membrane GO:0017038 - protein import GO:0022829 - wide pore channel activity GO:0031640 - killing of cells of another organism GO:0031904 - endosome lumen GO:0044194 - cytolytic granule GO:0051260 - protein homooligomerization GO:0051607 - defense response to virus GO:0051712 - positive regulation of killing of cells of another organism GO:0071806 - protein transmembrane transport GO:0140911 - pore-forming activity GO:0140507 - granzyme-mediated programmed cell death signaling pathway GO:1904856 - cytolytic granule lumen
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	555
Hs

1	555

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Last updated: 15 Jul 2024