Protein: EXOS4
Exosome complex component RRP41 (Exosome component 4) (Ribosomal RNA-processing protein 41) (p12A)

Gene: EXOS4, EXOSC4
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q9NPD3

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000460 - maturation of 5.8S rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1063768

EXOS7
Exosome complex component RRP42

10

19

Small-scale

0.977

High

986725

EXOS9
Exosome complex component RRP45

8

19

Small-scale

0.975

High

1046343

EXOS2
Exosome complex component RRP4

9

20

Small-scale

0.974

High

1342632

EXOS1
Exosome complex component CSL4

8

20

Small-scale

0.973

High

1284978

EXOS8
Exosome complex component RRP43

6

19

Small-scale

0.953

High

1257153

DI3L1
DIS3-like exonuclease 1

4

19

Small-scale

0.912

High

1130057

EXOS6
Exosome complex component MTR3

4

18

Small-scale

0.909

High

1342612

EXOS5
Exosome complex component RRP46

4

19

Small-scale

0.909

High

1342613

EXOS3
Exosome complex component RRP40

10

11

Small-scale

0.758

High

966487

EXOSX
Exosome complex component 10

8

9

Small-scale

0.752

High

1342631

RRP44
Exosome complex exonuclease RRP44

1

19

Small-scale

0.715

High

1304448

MPH6
M-phase phosphoprotein 6

5

6

Small-scale

0.714

High

1058042

RRP5
Protein RRP5 homolog

1

6

High-throughput

0.691

High

787017

MTREX
Exosome RNA helicase MTR4

3

13

Small-scale

0.667

High

1342633

HBS1L
HBS1-like protein

3

5

Small-scale

0.660

High

1047039

C1D
Nuclear nucleic acid-binding protein C1D

2

4

High-throughput

0.628

High

1342615

SAS10
Something about silencing protein 10

2

2

High-throughput

0.628

High

370496

ESR1
Estrogen receptor

3

12

High-throughput

0.624

High

1342611

EXOS4
Exosome complex component RRP41

1

18

Small-scale

0.621

High

1157905

ZCHC8
Zinc finger CCHC domain-containing protein 8

2

4

High-throughput

0.611

High

1342634

RBM7
RNA-binding protein 7

2

6

High-throughput

0.611

High

1252499

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

1085969

IF16
Gamma-interferon-inducible protein 16

2

6

High-throughput

0.584

High

133032

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

880361

DPOE2
DNA polymerase epsilon subunit 2

2

0

High-throughput

0.580

High

1201694

ZCH18
Zinc finger CCCH domain-containing protein 18

2

5

High-throughput

0.558

High

230430

ZC3H1
Zinc finger C3H1 domain-containing protein

1

6

High-throughput

0.536

High

453633

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

High-throughput

0.536

High

877368

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

9

High-throughput

0.536

High

908165

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

962388

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

1016330

TBL3
Transducin beta-like protein 3

1

11

High-throughput

0.536

High

1070042

PWP2
Periodic tryptophan protein 2 homolog

1

9

High-throughput

0.536

High

1167988

GGYF2
GRB10-interacting GYF protein 2

1

4

High-throughput

0.536

High

1199421

LYRIC
Protein LYRIC

1

1

High-throughput

0.536

High

1242460

PAPD5
Terminal nucleotidyltransferase 4B

1

3

High-throughput

0.536

High

1246482

WDR36
WD repeat-containing protein 36

1

10

High-throughput

0.536

High

1259970

PHF10
PHD finger protein 10

1

5

High-throughput

0.536

High

1263546

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1269690

ESR2
Estrogen receptor beta

1

12

High-throughput

0.536

High

1282715

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

7

High-throughput

0.536

High

1295409

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

High-throughput

0.536

High

1313442

WDR18
WD repeat-containing protein 18

1

2

High-throughput

0.536

High

1314135

AFG2B
ATPase family gene 2 protein homolog B

1

1

High-throughput

0.536

High

1326849

AICDA
Single-stranded DNA cytosine deaminase

1

6

Small-scale

0.536

High

1332402

NOL6
Nucleolar protein 6

1

2

High-throughput

0.536

High

1342618

SLTM
SAFB-like transcription modulator

1

1

High-throughput

0.536

High

1342629

WDR3
WD repeat-containing protein 3

1

14

High-throughput

0.536

High

1342630

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

High-throughput

0.536

High

1342635

UTP18
U3 small nucleolar RNA-associated protein 18 homolog

1

6

High-throughput

0.536

High

195845

TET3
Methylcytosine dioxygenase TET3

1

2

High-throughput

0.515

High

588945

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.513

High

642617

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

807543

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

828909

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

836784

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

848137

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.513

High

900276

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.513

High

911055

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.513

High

915089

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.513

High

971599

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.513

High

1057666

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.513

High

1092627

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.513

High

1161563

SHQ1
Protein SHQ1 homolog

1

0

High-throughput

0.513

High

1204997

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.513

High

1284095

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.513

High

1299382

RBM14
RNA-binding protein 14

1

0

High-throughput

0.513

High

1335771

CBX8
Chromobox protein homolog 8

1

0

High-throughput

0.513

High

1342617

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1342621

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.513

High

1342626

EI2BD
Translation initiation factor eIF2B subunit delta

1

0

High-throughput

0.513

High

1342636

NS1BP
Influenza virus NS1A-binding protein

1

0

High-throughput

0.513

High

285173

DXO
Decapping and exoribonuclease protein

1

1

High-throughput

0.508

High

537550

AK1A1
Aldo-keto reductase family 1 member A1

1

1

High-throughput

0.508

High

932881

EF1A1
Elongation factor 1-alpha 1

1

5

High-throughput

0.508

High

1048242

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

2

High-throughput

0.508

High

1074499

SKI2
Superkiller complex protein 2

1

14

High-throughput

0.508

High

1159943

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

1

High-throughput

0.508

High

1299974

NEK1
Serine/threonine-protein kinase Nek1

1

1

High-throughput

0.508

High

890851

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.501

High

1183844

LRC8D
Volume-regulated anion channel subunit LRRC8D

1

0

High-throughput

0.486

High

1251180

G45IP
Large ribosomal subunit protein mL64

1

0

High-throughput

0.486

High

1262119

SEN15
tRNA-splicing endonuclease subunit Sen15

1

0

High-throughput

0.486

High

1342625

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

0

High-throughput

0.486

High

992450

PPARA
Peroxisome proliferator-activated receptor alpha

1

12

High-throughput

0.481

High

123018

MEN1
Menin

1

4

High-throughput

0.479

High

125728

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

3

High-throughput

0.479

High

182919

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

198059

PHF1
PHD finger protein 1

1

1

High-throughput

0.479

High

237321

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

4

High-throughput

0.479

High

256079

OBSL1
Obscurin-like protein 1

1

3

High-throughput

0.479

High

268295

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

295284

RECQ4
ATP-dependent DNA helicase Q4

1

6

High-throughput

0.479

High

296675

SLIT2
Slit homolog 2 protein

1

1

High-throughput

0.479

High

298813

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

323176

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

9

High-throughput

0.479

High

326784

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

442517

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

504802

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

582510

NUCL
Nucleolin

1

1

High-throughput

0.479

High

616540

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

780152

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

826554

DHYS
Deoxyhypusine synthase

1

1

High-throughput

0.479

High

841330

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

841893

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

857015

THOP1
Thimet oligopeptidase

1

4

High-throughput

0.479

High

877907

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

909167

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

917975

H4
Histone H4

1

1

High-throughput

0.479

High

1022215

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

1064746

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1080373

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

1146860

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1153938

IFIX
Pyrin and HIN domain-containing protein 1

1

6

High-throughput

0.479

High

1171829

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1203144

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

1

Small-scale

0.479

High

1256411

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1270939

KAT6A
Histone acetyltransferase KAT6A

1

5

High-throughput

0.479

High

1281405

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

1294030

DDRGK
DDRGK domain-containing protein 1

1

4

High-throughput

0.479

High

1294810

RSRC1
Serine/Arginine-related protein 53

1

1

High-throughput

0.479

High

1306995

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

1331362

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

1334890

RENT2
Regulator of nonsense transcripts 2

1

2

Small-scale

0.479

High

1335181

RC3H2
Roquin-2

1

2

High-throughput

0.479

High

1336086

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

High-throughput

0.479

High

1342614

ANLN
Anillin

1

3

High-throughput

0.479

High

1342616

DCA13
DDB1- and CUL4-associated factor 13

1

5

Small-scale

0.479

High

1342619

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1342622

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

1342624

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1342628

FZR1
Fizzy-related protein homolog

1

5

High-throughput

0.479

High

1062792

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.460

High

149320

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

570594

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

0

High-throughput

0.458

High

807850

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

813767

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

897826

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

1081412

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1101309

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1272360

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

1327399

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.458

High

1328747

REN3A
Regulator of nonsense transcripts 3A

1

0

Small-scale

0.458

High

92721

E9PQZ5
PHD finger protein 1

1

1

High-throughput

0.445

High

110631

H3BNT4
M-phase phosphoprotein 6

1

6

High-throughput

0.445

High

1127706

PRC2B
Protein PRRC2B

1

2

High-throughput

0.439

High

385563

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

851131

LUM
Lumican

1

1

High-throughput

0.437

High

1230970

LRC47
Leucine-rich repeat-containing protein 47

1

1

High-throughput

0.437

High

1342627

HECD1
E3 ubiquitin-protein ligase HECTD1

1

7

High-throughput

0.437

High

306329

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

0

High-throughput

0.426

High

1130621

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

92537

E9PJN9
Ribosomal protein S3

1

1

High-throughput

0.407

High

533550

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

1292082

RM48
Large ribosomal subunit protein mL48

1

0

High-throughput

0.279

Low

1342623

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.279

Low

1342620

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.265

Low

311122

MPZL1
Myelin protein zero-like protein 1

1

0

High-throughput

0.251

Low

354569

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.249

Low

1053662

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024