HitPredict

Interactor 1: IRF2 (P14316)
Interferon regulatory factor 2 (IRF-2)
Gene: IRF2

Interactor 2: C2TA (P33076)
MHC class II transactivator (CIITA) (EC 2.3.1.-) (EC 2.7.11.1)
Gene: CIITA

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

Property	Details
Experiments	12493643, 17300840, 16982896, 15950283, 10956389, 10557076
Identification Methods	electrophoretic mobility supershift assay, electrophoretic mobility shift assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 349 Hs			1 1130
+	Mm
		621180 IRF2_MOUSE (1-349): 0: 525: 92.55		C2TA_MOUSE (19-1130): 0: 903: 69.56
+	Hs
		501004 IRF1_HUMAN (1-265): 1.74e-104: 311: 46.69		C2TA_HUMAN (1-1130): 0: 1032: 100.00
+	Hs
		702490 IRF4_HUMAN (7-145): 6.44e-63: 208: 39.57		C2TA_HUMAN (1-1130): 0: 1032: 100.00
+	Mm
		547395 IRF1_MOUSE (1-288): 4.16e-111: 328: 43.24		C2TA_MOUSE (19-1130): 0: 903: 69.56
+	Hs
		702482 IRF8_HUMAN (7-215): 1.4e-59: 199: 31.91		C2TA_HUMAN (1-1130): 0: 1032: 100.00
+	Mm
		945410 IRF4_MOUSE (7-146): 2.94e-66: 217: 40.00		C2TA_MOUSE (19-1130): 0: 903: 69.56
+	Mm
		619025 IRF8_MOUSE (7-215): 2.85e-60: 201: 30.14		NLRP3_MOUSE (834-1129): 1.35e-40: 165: 15.82