HitPredict

Interactor 1: DRD2 (P14416)
D(2) dopamine receptor (Dopamine D2 receptor)
Gene: DRD2

Interactor 2: DRD4 (P21917)
D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)
Gene: DRD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 21184734
Identification Methods anti tag coimmunoprecipitation
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~7tm_1
Common GO terms GO:0001591 - dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001975 - response to amphetamine
GO:0005886 - plasma membrane
GO:0006874 - intracellular calcium ion homeostasis
GO:0007195 - adenylate cyclase-inhibiting dopamine receptor signaling pathway
and 18 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 443
Hs

1 419
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024