Protein: HTRA3
Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease)

Gene: HTRA3
Organism: Homo sapiens
Interactions: 36
UniProt ID: P83110

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005576 - extracellular region
GO:0006508 - proteolysis
GO:0008236 - serine-type peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1013362

HTRA3
Serine protease HTRA3

3

17

Small-scale

0.876

High

1013284

HTRA4
Serine protease HTRA4

1

17

Small-scale

0.691

High

1013370

TMM25
Transmembrane protein 25

3

1

High-throughput

0.667

High

1013363

XIAP
E3 ubiquitin-protein ligase XIAP

3

15

Small-scale

0.630

High

610621

TCPA
T-complex protein 1 subunit alpha

1

2

Small-scale

0.551

High

1013364

DEF5
Defensin alpha 5

1

1

High-throughput

0.536

High

1013367

ROCK1
Rho-associated protein kinase 1

1

3

High-throughput

0.536

High

474614

VIME
Vimentin

1

1

Small-scale

0.529

High

721502

ILEU
Leukocyte elastase inhibitor

1

0

High-throughput

0.513

High

956046

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.513

High

1013375

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.513

High

952742

ACTB
Actin, cytoplasmic 1

1

4

Small-scale

0.506

High

457365

TBB5
Tubulin beta chain

1

4

Small-scale

0.501

High

270799

ROCK2
Rho-associated protein kinase 2

1

2

High-throughput

0.489

High

1013369

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.489

High

1013373

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

1013374

SH23A
SH2 domain-containing protein 3A

1

1

High-throughput

0.489

High

600790

HSP76
Heat shock 70 kDa protein 6

1

1

Small-scale

0.445

High

157236

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.437

High

445820

ENOA
Alpha-enolase

1

1

Small-scale

0.407

High

727763

DNJA1
DnaJ homolog subfamily A member 1

1

1

Small-scale

0.407

High

807369

IF4A3
Eukaryotic initiation factor 4A-III

1

2

Small-scale

0.407

High

912841

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

4

Small-scale

0.407

High

1013365

PRDX1
Peroxiredoxin-1

1

1

Small-scale

0.407

High

1013372

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

Small-scale

0.407

High

749320

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.279

Low

1013366

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1013371

CC4L
C-C motif chemokine 4-like

1

0

High-throughput

0.279

Low

324786

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

1013368

AP1AR
AP-1 complex-associated regulatory protein

1

0

High-throughput

0.249

Low

550982

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.232

Low

770150

RL22
Large ribosomal subunit protein eL22

1

0

Small-scale

0.232

Low

1012674

RT06
Small ribosomal subunit protein bS6m

1

0

Small-scale

0.232

Low

1013376

RUVB1
RuvB-like 1

1

0

Small-scale

0.232

Low

1013377

RT17
Small ribosomal subunit protein uS17m

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025