Interactor 1: LIN12 (P14585)
Protein lin-12 (Abnormal cell lineage protein 12) (Notch-like protein lin-12) [Cleaved into: lin-12/Notch intracellular domain]
Gene: lin-12

Interactor 2: LAG3 (Q09260)
Protein lag-3 (Abnormal cell lineage protein 3) (Abnormal germline proliferation protein 3)
Gene: sel-8

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.67 1.00 0.822

The method score is based on:

Property Details
Experiments 16530045, 15020414, 10830967
Identification Methods x-ray crystallography, two hybrid
Interaction Type association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Activator_LAG-3~Ank_2
Common GO terms GO:0005112 - Notch binding
GO:0005634 - nucleus
GO:0007219 - Notch signaling pathway
GO:0042661 - regulation of mesodermal cell fate specification
GO:0045893 - positive regulation of DNA-templated transcription
and 3 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 1429
Ce

1 490
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024