HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: NCF4 (Q15080)
Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (SH3 and PX domain-containing protein 4) (p40-phox) (p40phox)
Gene: NCF4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.79 1.00 0.894

The method score is based on:

Property Details
Experiments 11796733, 11258927, 9083043, 15657040
Identification Methods pull down, two hybrid, x-ray crystallography, classical fluorescence spectroscopy
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains NECFESHC~SH3_1, SH3_1~p47_phox_C, PX~PX, PB1~SH3_1, SH3_1~SH3_1
Common GO terms GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0016020 - membrane
GO:0016176 - superoxide-generating NADPH oxidase activator activity
and 4 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 390
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024