Protein: CO2A1
Collagen alpha-1(II) chain (Alpha-1 type II collagen) [Cleaved into: Collagen alpha-1(II) chain; Chondrocalcin]

Gene: CO2A1, COL2A1
Organism: Homo sapiens
Interactions: 57
UniProt ID: P02458

Gene Ontology (top 5):
GO:0001501 - skeletal system development
GO:0001502 - cartilage condensation
GO:0001894 - tissue homeostasis
GO:0001958 - endochondral ossification
GO:0002062 - chondrocyte differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

384241

CO9A1

4

17

Small-scale

0.899

High

384234

C1T9A
Complement C1q and tumor necrosis factor-related protein 9A

3

20

High-throughput

0.861

High

384266

C1QT2
Complement C1q tumor necrosis factor-related protein 2

3

20

High-throughput

0.861

High

384244

CO8A2
Collagen alpha-2(VIII) chain

3

19

High-throughput

0.847

High

73758

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

20

High-throughput

0.691

High

384226

C1QC
Complement C1q subcomponent subunit C

1

20

High-throughput

0.691

High

384245

CO8A1
Collagen alpha-1(VIII) chain

1

19

High-throughput

0.691

High

384265

C1QT1
Complement C1q tumor necrosis factor-related protein 1

1

20

High-throughput

0.691

High

384230

TSP1
Thrombospondin-1

1

8

Small-scale

0.647

High

384231

MMP2
72 kDa type IV collagenase

2

20

High-throughput

0.628

High

384239

MMP9
Matrix metalloproteinase-9

2

20

High-throughput

0.628

High

384260

GT252
Procollagen galactosyltransferase 2

2

20

High-throughput

0.628

High

384249

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

20

High-throughput

0.621

High

384225

CO2A1
Collagen alpha-1(II) chain

1

15

High-throughput

0.618

High

384076

CO1A1
Collagen alpha-1(I) chain

1

18

Small-scale

0.575

High

384256

Q4VAQ0
COL8A2 protein

1

20

High-throughput

0.575

High

333736

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

2

5

High-throughput

0.574

High

384269

CNPY2
Protein canopy homolog 2

2

1

High-throughput

0.574

High

384236

BMP2
Bone morphogenetic protein 2

1

8

Small-scale

0.561

High

384254

KEAP1
Kelch-like ECH-associated protein 1

2

17

High-throughput

0.553

High

384250

TF65
Transcription factor p65

1

1

High-throughput

0.541

High

376364

PDGFB
Platelet-derived growth factor subunit B

1

11

Small-scale

0.536

High

384238

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

11

High-throughput

0.536

High

384258

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

16

High-throughput

0.536

High

384261

OSCAR
Osteoclast-associated immunoglobulin-like receptor

1

16

High-throughput

0.536

High

384251

HYAL1
Hyaluronidase-1

1

0

High-throughput

0.518

High

130904

HIP1
Huntingtin-interacting protein 1

1

1

High-throughput

0.515

High

326993

NXPH2
Neurexophilin-2

1

0

High-throughput

0.513

High

215694

COCH
Cochlin

1

13

Small-scale

0.501

High

376658

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

8

Small-scale

0.501

High

384228

PDGFA
Platelet-derived growth factor subunit A

1

11

Small-scale

0.501

High

384232

ITA2B
Integrin alpha-IIb

1

5

Small-scale

0.501

High

384233

ANXA5
Annexin A5

1

4

Small-scale

0.501

High

384242

MAG
Myelin-associated glycoprotein

1

5

Small-scale

0.501

High

384246

PRELP
Prolargin

1

3

Small-scale

0.501

High

384248

PKD1
Polycystin-1

1

1

Small-scale

0.501

High

384252

PDIA2
Protein disulfide-isomerase A2

1

7

Small-scale

0.501

High

384229

GELS
Gelsolin

1

0

High-throughput

0.493

High

384237

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

384243

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.493

High

352822

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.479

High

384235

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

384240

TIMP2
Metalloproteinase inhibitor 2

1

7

High-throughput

0.479

High

384268

UBQL1
Ubiquilin-1

1

3

High-throughput

0.470

High

384227

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.437

High

384253

CUL3
Cullin-3

1

12

High-throughput

0.437

High

384259

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.437

High

384263

ASB11
Ankyrin repeat and SOCS box protein 11

1

3

High-throughput

0.437

High

384257

KLH22
Kelch-like protein 22

1

20

High-throughput

0.407

High

384267

CHODL
Chondrolectin

1

0

High-throughput

0.279

Low

280451

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.268

Low

384247

CASP6
Caspase-6

1

0

High-throughput

0.268

Low

384255

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

0

High-throughput

0.268

Low

384262

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.268

Low

384270

Q9Y649
GW128

1

0

High-throughput

0.268

Low

384264

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025