HitPredict

Interactor 1: NCF1 (P14598)
Neutrophil cytosol factor 1 (NCF-1) (47 kDa autosomal chronic granulomatous disease protein) (47 kDa neutrophil oxidase factor) (NCF-47K) (Neutrophil NADPH oxidase factor 1) (Nox organizer 2) (Nox-organizing protein 2) (SH3 and PX domain-containing protein 1A) (p47-phox)
Gene: NCF1

Interactor 2: SH3G1 (Q99961)
Endophilin-A2 (EEN fusion partner of MLL) (Endophilin-2) (Extra eleven-nineteen leukemia fusion gene protein) (EEN) (SH3 domain protein 2B) (SH3 domain-containing GRB2-like protein 1)
Gene: SH3GL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	30833792
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	NECFESHC~SH3_1, SH3_1~p47_phox_C, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 390 Hs			1 368
+	Hs
		537667 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SH3G3_HUMAN (1-368): 1.31e-87: 270: 66.30
+	Hs
		63093 NCF1B_HUMAN (1-390): 1.01e-100: 305: 98.98		SH3G3_HUMAN (1-368): 1.31e-87: 270: 66.30
+	Hs
		537645 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16
+	Hs
		537649 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		NCF4_HUMAN (294-368): 9.33e-22: 96.4: 37.33
+	Hs
		1307414 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		SH3G1_HUMAN (1-368): 7.32e-90: 276: 100.00
+	Hs
		1307430 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		SH3G3_HUMAN (1-368): 1.31e-87: 270: 66.30
+	Hs
		1307429 SH3G2_HUMAN (6-211): 5.16e-32: 125: 10.68		SH3G2_HUMAN (1-368): 1.98e-84: 261: 68.75
+	Hs
		537657 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		SH3R1_HUMAN (305-361): 9.5e-13: 71.7: 49.18
+	Hs
		537619 NCF1_HUMAN (1-390): 1.2e-102: 310: 100.00		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Rn
		192737 SRBS2_RAT (163-283): 2.18e-21: 98.4: 21.15		SH3G1_RAT (1-368): 5.26e-88: 271: 92.94
+	Hs
		1052195 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		SRC8_HUMAN (35-362): 1.55e-37: 143: 12.16
+	Rn
		71363 B2RZ33_RAT (130-350): 1.82e-33: 130: 17.16		SRC8_RAT (86-362): 8.29e-37: 140: 14.75
+	Hs
		1052226 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		RHG17_HUMAN (6-267): 6.29e-35: 137: 21.83
+	Hs
		1045408 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		SPTN1_HUMAN (4-365): 1.47e-33: 134: 15.82
+	Rn
		192738 SRBS2_RAT (163-283): 2.18e-21: 98.4: 21.15		SPTN1_RAT (4-365): 2.16e-33: 133: 16.62
+	Hs
		557655 NCK1_HUMAN (130-350): 9.29e-34: 131: 17.16		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		924570 SRC8_HUMAN (4-282): 7.5e-33: 131: 12.67		GRB2_HUMAN (311-367): 1.59e-11: 65.2: 41.38
+	Hs
		298986 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		SH3R1_HUMAN (305-361): 9.5e-13: 71.7: 49.18
+	Hs
		298942 SRBS2_HUMAN (163-283): 1.9e-20: 95.7: 21.15		SRBS2_HUMAN (270-363): 9.46e-12: 68.6: 23.96
+	Hs
		208967 NCK2_HUMAN (161-327): 3.03e-19: 90.2: 14.98		SRBS2_HUMAN (270-363): 9.46e-12: 68.6: 23.96