Protein: ZUP1
Zinc finger-containing ubiquitin peptidase 1 (EC 3.4.19.12) (Lys-63-specific deubiquitinase ZUFSP) (DUB) (Zinc finger with UFM1-specific peptidase domain protein)

Gene: ZUP1
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q96AP4

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508396

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

4

4

Small-scale

0.926

High

696152

RFA1
Replication protein A 70 kDa DNA-binding subunit

4

1

Small-scale

0.676

High

1143845

TCAL1
Transcription elongation factor A protein-like 1

4

0

Small-scale

0.664

High

325971

UBR5
E3 ubiquitin-protein ligase UBR5

3

2

Small-scale

0.640

High

589356

RFA2
Replication protein A 32 kDa subunit

3

1

Small-scale

0.640

High

768840

RFA3
Replication protein A 14 kDa subunit

3

2

Small-scale

0.640

High

856850

BAG6
Large proline-rich protein BAG6

1

3

Small-scale

0.618

High

987441

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

1

Small-scale

0.618

High

1365829

HMHA1
Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1

2

6

High-throughput

0.606

High

894435

MMP14
Matrix metalloproteinase-14

2

0

High-throughput

0.580

High

907526

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

0

Small-scale

0.559

High

842826

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

1

High-throughput

0.541

High

564176

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

1357927

Q8WVC2
40S ribosomal protein S21

1

1

High-throughput

0.515

High

162654

ANM5
Protein arginine N-methyltransferase 5

1

0

High-throughput

0.486

High

992515

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.481

High

134113

IPO5
Importin-5

1

2

Small-scale

0.479

High

173188

XPO1
Exportin-1

1

4

Small-scale

0.479

High

257154

CCD22
Coiled-coil domain-containing protein 22

1

2

High-throughput

0.479

High

262415

DTNB
Dystrobrevin beta

1

1

High-throughput

0.479

High

385154

K1C14
Keratin, type I cytoskeletal 14

1

8

Small-scale

0.479

High

385312

K2C6A
Keratin, type II cytoskeletal 6A

1

7

Small-scale

0.479

High

407327

K2C6B
Keratin, type II cytoskeletal 6B

1

7

Small-scale

0.479

High

407503

K2C1
Keratin, type II cytoskeletal 1

1

7

Small-scale

0.479

High

408128

TBB4A
Tubulin beta-4A chain

1

3

Small-scale

0.479

High

409024

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.479

High

457606

TBB5
Tubulin beta chain

1

3

Small-scale

0.479

High

474879

VIME
Vimentin

1

6

Small-scale

0.479

High

476370

K1C16
Keratin, type I cytoskeletal 16

1

8

Small-scale

0.479

High

535386

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

537666

HSP7C
Heat shock cognate 71 kDa protein

1

3

Small-scale

0.479

High

551581

K2C3
Keratin, type II cytoskeletal 3

1

6

Small-scale

0.479

High

566196

K1C10
Keratin, type I cytoskeletal 10

1

9

Small-scale

0.479

High

566300

K1C13
Keratin, type I cytoskeletal 13

1

8

Small-scale

0.479

High

566433

K2C5
Keratin, type II cytoskeletal 5

1

6

Small-scale

0.479

High

570540

GFAP
Glial fibrillary acidic protein

1

6

Small-scale

0.479

High

577849

PLAK
Junction plakoglobin

1

3

Small-scale

0.479

High

652383

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

Small-scale

0.479

High

727916

DNJA1
DnaJ homolog subfamily A member 1

1

1

Small-scale

0.479

High

761475

HS71L
Heat shock 70 kDa protein 1-like

1

3

Small-scale

0.479

High

772043

K1C9
Keratin, type I cytoskeletal 9

1

10

Small-scale

0.479

High

777533

K22E
Keratin, type II cytoskeletal 2 epidermal

1

7

Small-scale

0.479

High

846651

MSH2
DNA mismatch repair protein Msh2

1

2

High-throughput

0.479

High

862686

UTRN
Utrophin

1

1

High-throughput

0.479

High

881267

FAS
Fatty acid synthase

1

1

Small-scale

0.479

High

886550

CTCF
Transcriptional repressor CTCF

1

3

High-throughput

0.479

High

888801

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

3

High-throughput

0.479

High

913373

MSH6
DNA mismatch repair protein Msh6

1

2

High-throughput

0.479

High

931043

HSP72
Heat shock-related 70 kDa protein 2

1

3

Small-scale

0.479

High

934132

XPO2
Exportin-2

1

11

Small-scale

0.479

High

953021

ACTB
Actin, cytoplasmic 1

1

2

Small-scale

0.479

High

958485

ACTZ
Alpha-centractin

1

3

High-throughput

0.479

High

977789

ACTA
Actin, aortic smooth muscle

1

2

Small-scale

0.479

High

1036781

DSG1
Desmoglein-1

1

2

Small-scale

0.479

High

1047468

K1C17
Keratin, type I cytoskeletal 17

1

8

Small-scale

0.479

High

1058907

ZO1
Tight junction protein 1

1

1

High-throughput

0.479

High

1100205

TIF1B
Transcription intermediary factor 1-beta

1

20

Small-scale

0.479

High

1124004

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

1157853

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

1178613

KIF7
Kinesin-like protein KIF7

1

1

High-throughput

0.479

High

1212820

UBR4
E3 ubiquitin-protein ligase UBR4

1

2

Small-scale

0.479

High

1228448

FTM
Protein fantom

1

1

High-throughput

0.479

High

1235620

K2C80
Keratin, type II cytoskeletal 80

1

5

Small-scale

0.479

High

1259402

TBA1A
Tubulin alpha-1A chain

1

1

Small-scale

0.479

High

1280849

K2C1B
Keratin, type II cytoskeletal 1b

1

7

Small-scale

0.479

High

1291119

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

Small-scale

0.479

High

1295203

HOME1
Homer protein homolog 1

1

2

High-throughput

0.479

High

1323681

K2C78
Keratin, type II cytoskeletal 78

1

8

Small-scale

0.479

High

1363074

DDB2
DNA damage-binding protein 2

1

1

High-throughput

0.479

High

1369731

RAD50
DNA repair protein RAD50

1

1

High-throughput

0.479

High

1383395

DHRS4
Dehydrogenase/reductase SDR family member 4

1

1

High-throughput

0.479

High

1383399

PECR
Peroxisomal trans-2-enoyl-CoA reductase

1

2

High-throughput

0.479

High

1383402

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

Small-scale

0.479

High

1383404

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

3

High-throughput

0.479

High

1383408

DECR2
Peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

1

2

High-throughput

0.479

High

1383410

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

3

High-throughput

0.479

High

1383414

ZO2
Tight junction protein 2

1

1

High-throughput

0.479

High

1383416

INO80
Chromatin-remodeling ATPase INO80

1

1

High-throughput

0.479

High

67493

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.458

High

252895

EXOC3
Exocyst complex component 3

1

0

High-throughput

0.458

High

271367

DEPD5
GATOR1 complex protein DEPDC5

1

0

High-throughput

0.458

High

291950

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

0

High-throughput

0.458

High

370348

CYTA
Cystatin-A

1

0

Small-scale

0.458

High

400003

CATA
Catalase

1

0

Small-scale

0.458

High

423690

ARGI1
Arginase-1

1

0

Small-scale

0.458

High

456818

ANXA2
Annexin A2

1

0

Small-scale

0.458

High

506703

CTF8
Chromosome transmission fidelity protein 8 homolog

1

0

High-throughput

0.458

High

637936

NF1
Neurofibromin

1

0

High-throughput

0.458

High

662481

GATA2
Endothelial transcription factor GATA-2

1

0

High-throughput

0.458

High

680975

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.458

High

697612

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.458

High

723041

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.458

High

729599

CASPE
Caspase-14

1

0

Small-scale

0.458

High

839336

MTOR
Serine/threonine-protein kinase mTOR

1

0

High-throughput

0.458

High

841228

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.458

High

846413

MATR3
Matrin-3

1

0

Small-scale

0.458

High

910624

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

Small-scale

0.458

High

926392

BLM
RecQ-like DNA helicase BLM

1

0

High-throughput

0.458

High

940494

DPOE2
DNA polymerase epsilon subunit 2

1

0

High-throughput

0.458

High

953960

IF4A1
Eukaryotic initiation factor 4A-I

1

0

Small-scale

0.458

High

1005931

GTF2I
General transcription factor II-I

1

0

High-throughput

0.458

High

1007190

TCPB
T-complex protein 1 subunit beta

1

0

Small-scale

0.458

High

1024127

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

1060468

DPOE1
DNA polymerase epsilon catalytic subunit A

1

0

High-throughput

0.458

High

1118237

BLMH
Bleomycin hydrolase

1

0

Small-scale

0.458

High

1132883

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

1217173

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.458

High

1217270

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

High-throughput

0.458

High

1241726

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.458

High

1243028

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.458

High

1244567

SYDM
Aspartate--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1246917

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1280397

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

Small-scale

0.458

High

1295438

C2CD5
C2 domain-containing protein 5

1

0

High-throughput

0.458

High

1323120

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

1323317

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

0

High-throughput

0.458

High

1357874

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

High-throughput

0.458

High

1383387

DOC10
Dedicator of cytokinesis protein 10

1

0

High-throughput

0.458

High

1383394

FNBP1
Formin-binding protein 1

1

0

High-throughput

0.458

High

1383396

DCC1
Sister chromatid cohesion protein DCC1

1

0

High-throughput

0.458

High

1383397

LST8
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.458

High

1383398

AFG2B
ATPase family gene 2 protein homolog B

1

0

High-throughput

0.458

High

1383400

HELZ2
3'-5' exoribonuclease HELZ2

1

0

High-throughput

0.458

High

1383401

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

0

High-throughput

0.458

High

1383407

DPOE4
DNA polymerase epsilon subunit 4

1

0

High-throughput

0.458

High

1383409

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.458

High

1383415

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

0

High-throughput

0.458

High

1383417

TIM
Protein timeless homolog

1

0

High-throughput

0.458

High

1383418

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.458

High

1062281

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

2

Small-scale

0.437

High

1064466

DSC1
Desmocollin-1

1

5

Small-scale

0.437

High

1108658

TBB3
Tubulin beta-3 chain

1

3

Small-scale

0.437

High

1118553

TBB2A
Tubulin beta-2A chain

1

3

Small-scale

0.437

High

1200055

EIPR1
EARP and GARP complex-interacting protein 1

1

1

High-throughput

0.437

High

1204018

FILA2
Filaggrin-2

1

5

Small-scale

0.437

High

1251588

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

3

High-throughput

0.437

High

1295697

HORN
Hornerin

1

5

Small-scale

0.437

High

1316850

ASPM
Abnormal spindle-like microcephaly-associated protein

1

1

Small-scale

0.437

High

1351301

DMXL2
DmX-like protein 2

1

1

High-throughput

0.437

High

1383389

VPS39
Vam6/Vps39-like protein

1

3

High-throughput

0.437

High

1383390

IFT74
Intraflagellar transport protein 74 homolog

1

2

High-throughput

0.437

High

1383406

TBB1
Tubulin beta-1 chain

1

4

Small-scale

0.437

High

1337560

SHCBP
SHC SH2 domain-binding protein 1

1

0

High-throughput

0.282

High

1383413

CLN8
Protein CLN8

1

0

Small-scale

0.251

Low

171097

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.249

Low

216016

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.249

Low

321931

FRYL
Protein furry homolog-like

1

0

High-throughput

0.249

Low

377224

SOMA
Somatotropin

1

0

Small-scale

0.249

Low

390132

ALBU
Albumin

1

0

Small-scale

0.249

Low

587764

DESP
Desmoplakin

1

0

Small-scale

0.249

Low

774788

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.249

Low

932921

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.249

Low

1010690

DCD
Dermcidin

1

0

Small-scale

0.249

Low

1048624

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

Small-scale

0.249

Low

1201145

CCD93
Coiled-coil domain-containing protein 93

1

0

High-throughput

0.249

Low

1211533

SZT2
KICSTOR complex protein SZT2

1

0

High-throughput

0.249

Low

1211895

FKB15
FK506-binding protein 15

1

0

High-throughput

0.249

Low

1213801

KPRP
Keratinocyte proline-rich protein

1

0

Small-scale

0.249

Low

1292706

IT70A
Intraflagellar transport protein 70A

1

0

High-throughput

0.249

Low

1383386

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

1383388

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

1383391

KICS2
KICSTOR subunit 2

1

0

High-throughput

0.249

Low

1383392

SPB12
Serpin B12

1

0

Small-scale

0.249

Low

1383393

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.249

Low

1383403

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.249

Low

1383405

CPVL
Probable serine carboxypeptidase CPVL

1

0

Small-scale

0.249

Low

1383411

RELCH
RAB11-binding protein RELCH

1

0

Small-scale

0.249

Low

1383412

IFT80
Intraflagellar transport protein 80 homolog

1

0

High-throughput

0.249

Low

1383419

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

0

High-throughput

0.249

Low

1383420

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025