HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FKBP_C~PK_Tyr_Ser-Thr
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1297 Hs			1 457
+	Hs
		118686 INSRR_HUMAN (1-1297): 0: 1365: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		537740 INSRR_HUMAN (1-1297): 0: 1365: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		435726 IGF1R_HUMAN (9-1265): 0: 1222: 55.39		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51
+	Hs
		411467 INSR_HUMAN (27-1288): 0: 1183: 52.18		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51
+	Hs
		872531 EPHB4_HUMAN (455-1269): 0: 581: 21.32		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		171301 EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		118695 EPHA8_HUMAN (454-1268): 2.42e-179: 558: 20.16		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118645 EPHB6_HUMAN (645-1291): 7.18e-161: 510: 23.91		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		169174 MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		384787 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		384676 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		1128922 EPHAA_HUMAN (657-1253): 2.9e-139: 452: 23.91		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51
+	Hs
		118696 LTK_HUMAN (969-1291): 4.92e-73: 264: 42.17		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		118739 NTRK2_HUMAN (957-1253): 1.12e-67: 247: 42.43		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		384721 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		PPID_HUMAN (249-414): 4.11e-51: 178: 24.55
+	Hs
		118668 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		384834 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		384359 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		601874 ERBB3_HUMAN (2-296): 3.16e-34: 145: 18.24		FKB1A_HUMAN (151-247): 2.87e-21: 90.3: 26.73
+	Hs
		923826 ERBB4_HUMAN (342-482): 7.06e-15: 82.4: 19.73		FKB1A_HUMAN (151-247): 2.87e-21: 90.3: 26.73